A study of the localization of polynucleotide phosphorylase within rat liver cells and of its distribution among rat tissues and diverse animal species

1. Rat liver polynucleotide phosphorylase was localized in the mitochondrion, but may also occur in the nucleus. 2. The mitochondrial enzyme was found in rat heart, kidney, liver, muscle and spleen. 3. Mitochondrial polynucleotide phosphorylase is also present in calf, chicken, guinea-pig and rabbit...

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Veröffentlicht in:	Biochemical journal 1972-11, Vol.130 (2), p.355-362
Hauptverfasser:	See, Y P, Fitt, P S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Animals Cattle Cell Fractionation Cell Nucleus - enzymology Chickens Cyprinidae Guinea Pigs Kidney - enzymology Liver - enzymology Microsomes, Liver - enzymology Mitochondria, Liver - enzymology Mitochondria, Muscle - enzymology Muscles - enzymology Myocardium - enzymology Osmosis Phosphorus Isotopes Polyribonucleotide Nucleotidyltransferase - analysis Rabbits Rats RNA Nucleotidyltransferases - analysis Spleen - enzymology
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Beschreibung
Zusammenfassung:	1. Rat liver polynucleotide phosphorylase was localized in the mitochondrion, but may also occur in the nucleus. 2. The mitochondrial enzyme was found in rat heart, kidney, liver, muscle and spleen. 3. Mitochondrial polynucleotide phosphorylase is also present in calf, chicken, guinea-pig and rabbit liver and in goldfish muscle. 4. A possible physiological role for the enzyme in the control of the intramitochondrial ADP concentration is suggested.
ISSN:	0264-6021 0306-3283 1470-8728
DOI:	10.1042/bj1300355