Quality‐of‐Life Outcomes Following Endoscopic Resection of Sinonasal Inverted Papilloma

Objectives There is growing interest in assessing patient quality of life (QOL) following treatment of sinonasal tumors, including inverted papilloma (IP). We aimed to elucidate the natural history of postoperative QOL outcomes in IP patients treated with surgery. Methods Cases of sinonasal IP treated surgically at 4 tertiary academic rhinology centers were retrospectively reviewed. SNOT‐22 scores were used to evaluate QOL preoperatively and postoperatively (1, 3, 6, 12 months). Repeated‐measures ANOVA assessed for differences in mean scores over time. Linear regression identified factors associated with QOL longitudinally. Results 373 patients were analyzed. Mean preoperative SNOT‐22 score was 20.6 ± 20.4, which decreased to 16.3 ± 18.8 (p = 0.041) and 11.8 ± 15.0 (p 0.05). When analyzed by SNOT‐22 subdomains, nasal, sleep, and otologic/facial subdomain scores (all p 0.05). Conclusions QOL outcomes related to IP resection are largely driven by nasal, sleep, and otologic/facial subdomains, though patients appear to experience enduring improvement as early as 3 months postoperatively. Recurrent disease is a major driver of negative QOL. Level of Evidence 4 Laryngoscope, 135:579–585, 2025 In this multi‐institutional longitudinal study of 373 inverted papilloma patients, surgical resection significantly improved quality of life (QOL) within 1 month of surgery, which improved in a durable manner at 3 months postoperatively and stabilized across 12 months. QOL outcomes were largely driven by nasal, sleep, and otologic/facial symptoms.