Longitudinal neurodegeneration in Early‐Onset Alzheimer’s Disease: A summary of MRI‐derived atrophy in LEADS

Background Prior work has advanced our understanding of cortical atrophy in early‐onset Alzheimer’s disease (EOAD), but longitudinal data are sparse. Current longitudinal MRI studies point to progressive atrophy in cerebral cortex exhibiting a posterior‐to‐anterior gradient, but these studies include small samples with mostly amnestic EOAD. Here, we analyzed a large sample of sporadic EOAD patients from the Longitudinal Early‐Onset Alzheimer's Disease Study (LEADS) to test the central hypothesis that areas in our recently described EOAD signature (Touroutoglou et al., 2023) affected at baseline in the posterior lateral temporal cortex, inferior parietal lobule, and PCC/precuneus will continue to degenerate and additional longitudinal atrophy will be found in the medial temporal lobe and frontal regions as cognitive decline progresses over time in multiple domains. Method We investigated longitudinal changes in cortical thickness by analyzing structural MRI data collected from 367 patients with EOAD and 99 cognitively unimpaired (CN) older adults, totaling 839 MRI scans across the cohorts with up to 4 years of follow‐up. MRI data were longitudinally processed in FreeSurfer 6.0. Linear mixed effects models were constructed to estimate the rate of cortical atrophy with random intercepts and slopes for individual participants while controlling for baseline age and sex. Result EOAD patients exhibited cortical atrophy at a faster rate than controls in widespread areas of the cerebral cortex. As expected, the regions exhibiting accelerated longitudinal atrophy included not only the EOAD signature regions as a whole (EOAD: ‐0.052±0.002 mm/year vs. CN: 0.0001±0.002 mm/year; Dslopes = ‐0.052, p