Unraveling the Early Trajectory of Cortical Tau Accumulation Using 18F‐MK6240

Unraveling the Early Trajectory of Cortical Tau Accumulation Using 18F‐MK6240

Background Tau PET is instrumental in tracking the longitudinal progression of Alzheimer's disease (AD). 18F‐MK6240 is a high affinity tracer targeting the 3R/4R paired helical filaments of tau in AD. We aimed to evaluate the early phase of the natural progression of tau accumulation using 18F‐...

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Veröffentlicht in:Alzheimer's & dementia 2024-12, Vol.20 (S2), p.n/a
Hauptverfasser: Dore, Vincent, Krishnadas, Natasha, Bourgeat, Pierrick, Leuzy, Antoine, Feizpour, Azadeh, Cox, Timothy, Huang, Kun, Haeberlein, Samantha Budd, Fripp, Jurgen, Villemagne, Victor L, Rowe, Christopher C.
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Sprache:eng
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Biomarkers
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Zusammenfassung:Background Tau PET is instrumental in tracking the longitudinal progression of Alzheimer's disease (AD). 18F‐MK6240 is a high affinity tracer targeting the 3R/4R paired helical filaments of tau in AD. We aimed to evaluate the early phase of the natural progression of tau accumulation using 18F‐MK6240. Method 231 participants: 100 cognitively unimpaired (CU) Aβ− (Centiloid50 & age13 or CTR rate>0) only. Given the limited numbers of individuals with CTR>100, our analysis concentrated on the early phase of tau accumulation (CTR
ISSN:1552-5260
1552-5279
DOI:10.1002/alz.090604