The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis
Ankle osteoarthritis is a debilitating condition that significantly impairs patients' quality of life. Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorder...
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| Veröffentlicht in: | Journal of orthopaedic surgery and research 2024-12, Vol.19 (1), p.895, Article 895 |
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| creator | Ding, Qixin Wang, Xu Liu, Yurong Li, Yuefang Zhang, Di Wang, Heling Ma, Shenhong Han, Qiaohua Zhuang, Weisheng |
| description | Ankle osteoarthritis is a debilitating condition that significantly impairs patients' quality of life. Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorders, so as to provide strong evidence in support of clinical treatment.
A comprehensive and systematic search of PubMed, the Cochrane Library, Embase and web of science databases was performed, and studies that met the requirements according to the inclusion criteria were analyzed using Review Manager and STATA version 14.0. Quality assessment was performed using the Cochrane Collaboration Risk of Bias 2.0 tool. The outcome indicators were the American Orthopaedic Foot and Ankle Society Rating Scale (AOFAS) and Visual Analog Scale (VAS) scores used to evaluate the efficacy of platelet-rich plasma.
A total of 10 studies met the inclusion criteria. Regarding the AOFAS score, a meta-analysis that included five randomized controlled trials (each study extracted the score results at the last follow-up time) showed no statistically significant differences between the platelet-rich plasma intervention group and the control group, and there was a great deal of heterogeneity in the results, with subgroup analyses based on disease type. (Mean Difference = 4.14, 95% CI=-0.60-8.87, p = 0.09, I
= 86%). Subgroup analysis showed a more significant effect in patients with talar cartilage injuries (Mean Difference = 8.66, 95%CI = 6.61-10.71, p |
| doi_str_mv | 10.1186/s13018-024-05420-5 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11689593</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A821956702</galeid><sourcerecordid>A821956702</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1833-d2520df259612100caf310e421e4c2cf66b3b2cfc84ec353fcd08c80ccd51da73</originalsourceid><addsrcrecordid>eNpVkU1v1DAQhi0Eou3CH-CALHHhYvBn4nBBVQUFqRKXInFAsmYn467BSZY4W7T_Hi9bqnIaW37m1Ywfxl4o-UYp37wtykjlhdRWSGe1FO4RO1Wt7UTbdd8ePzifsLNSfkjppPP2KTsxXWuVsfqUfb_eEKcYEwLu-RT5NsNCmRYxJ9wcbmUAnkYO489MvE-FoNA7Drzsy0IDLAn5TLeJflek5wMtIGCEvC-pPGNPIuRCz-_qin39-OH64pO4-nL5-eL8SqDyxoheOy37qF3XKK2kRIhGSbJakUWNsWnWZl0rektonInYS49eIvZO9dCaFXt_zN3u1gP1SOMyQw7bOQ0w78MEKfz_MqZNuJlug1KN71xnasLru4R5-rWjsoQhFaScYaRpV4JR9eu09nXeFXt1RG8gU0hjnGokHvBw7rXqXNNKXSl9pHCeSpkp3k-jZDjYC0d7odoLf-0FV5tePtzjvuWfLvMHWYCWIw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3150522818</pqid></control><display><type>article</type><title>The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>Springer Nature OA Free Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>SpringerLink Journals - AutoHoldings</source><creator>Ding, Qixin ; Wang, Xu ; Liu, Yurong ; Li, Yuefang ; Zhang, Di ; Wang, Heling ; Ma, Shenhong ; Han, Qiaohua ; Zhuang, Weisheng</creator><creatorcontrib>Ding, Qixin ; Wang, Xu ; Liu, Yurong ; Li, Yuefang ; Zhang, Di ; Wang, Heling ; Ma, Shenhong ; Han, Qiaohua ; Zhuang, Weisheng</creatorcontrib><description>Ankle osteoarthritis is a debilitating condition that significantly impairs patients' quality of life. Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorders, so as to provide strong evidence in support of clinical treatment.
A comprehensive and systematic search of PubMed, the Cochrane Library, Embase and web of science databases was performed, and studies that met the requirements according to the inclusion criteria were analyzed using Review Manager and STATA version 14.0. Quality assessment was performed using the Cochrane Collaboration Risk of Bias 2.0 tool. The outcome indicators were the American Orthopaedic Foot and Ankle Society Rating Scale (AOFAS) and Visual Analog Scale (VAS) scores used to evaluate the efficacy of platelet-rich plasma.
A total of 10 studies met the inclusion criteria. Regarding the AOFAS score, a meta-analysis that included five randomized controlled trials (each study extracted the score results at the last follow-up time) showed no statistically significant differences between the platelet-rich plasma intervention group and the control group, and there was a great deal of heterogeneity in the results, with subgroup analyses based on disease type. (Mean Difference = 4.14, 95% CI=-0.60-8.87, p = 0.09, I
= 86%). Subgroup analysis showed a more significant effect in patients with talar cartilage injuries (Mean Difference = 8.66, 95%CI = 6.61-10.71, p < 0.00001, I
= 0%). And the treatment effect of PRP remained effective in long-term follow-up (Mean Difference = 7.83, 95% CI = 5.57-10.09, p = 0.46, I
= 0%). For VAS scores, PRP relieved patients' pain (Standardized Mean Difference=-0.62, 95%CI=-1.13-0.10, p = 0.02, I
= 77%) but showed a greater advantage in patients with cartilage injuries of the talus (Standardized Mean Difference=-1.24, 95%CI=-1.68-0.81, p < 0.00001, I
= 0%). Subgroup analyses according to different disease types and different follow-up times showed that PRP had significant efficacy in talar cartilage injuries in both the short and long term. A meta-analysis of single-arm studies showed that PRP was helpful in improving patients' pain before and after the intervention (Standardized Mean Difference = -1.76, 95% CI = -2.85 to -0.67, p = 0.002, I^2 = 87%).However, the high level of heterogeneity may be due to the large differences between the inclusion criteria of the single-arm studies.
More clinical studies are needed to further confirm the efficacy of platelet-rich plasma in ankle disorders, and the current study only suggests that platelet-rich plasma may be more effective in talus cartilage injuries than in other types of ankle disorders.</description><identifier>ISSN: 1749-799X</identifier><identifier>EISSN: 1749-799X</identifier><identifier>DOI: 10.1186/s13018-024-05420-5</identifier><identifier>PMID: 39741342</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Analysis ; Ankle Joint ; Care and treatment ; Diseases ; Humans ; Medical research ; Medicine, Experimental ; Online databases ; Osteoarthritis ; Osteoarthritis - therapy ; Pain ; Platelet-Rich Plasma ; Randomized Controlled Trials as Topic ; Systematic Review ; Treatment Outcome</subject><ispartof>Journal of orthopaedic surgery and research, 2024-12, Vol.19 (1), p.895, Article 895</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1833-d2520df259612100caf310e421e4c2cf66b3b2cfc84ec353fcd08c80ccd51da73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11689593/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11689593/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39741342$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ding, Qixin</creatorcontrib><creatorcontrib>Wang, Xu</creatorcontrib><creatorcontrib>Liu, Yurong</creatorcontrib><creatorcontrib>Li, Yuefang</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Wang, Heling</creatorcontrib><creatorcontrib>Ma, Shenhong</creatorcontrib><creatorcontrib>Han, Qiaohua</creatorcontrib><creatorcontrib>Zhuang, Weisheng</creatorcontrib><title>The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis</title><title>Journal of orthopaedic surgery and research</title><addtitle>J Orthop Surg Res</addtitle><description>Ankle osteoarthritis is a debilitating condition that significantly impairs patients' quality of life. Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorders, so as to provide strong evidence in support of clinical treatment.
A comprehensive and systematic search of PubMed, the Cochrane Library, Embase and web of science databases was performed, and studies that met the requirements according to the inclusion criteria were analyzed using Review Manager and STATA version 14.0. Quality assessment was performed using the Cochrane Collaboration Risk of Bias 2.0 tool. The outcome indicators were the American Orthopaedic Foot and Ankle Society Rating Scale (AOFAS) and Visual Analog Scale (VAS) scores used to evaluate the efficacy of platelet-rich plasma.
A total of 10 studies met the inclusion criteria. Regarding the AOFAS score, a meta-analysis that included five randomized controlled trials (each study extracted the score results at the last follow-up time) showed no statistically significant differences between the platelet-rich plasma intervention group and the control group, and there was a great deal of heterogeneity in the results, with subgroup analyses based on disease type. (Mean Difference = 4.14, 95% CI=-0.60-8.87, p = 0.09, I
= 86%). Subgroup analysis showed a more significant effect in patients with talar cartilage injuries (Mean Difference = 8.66, 95%CI = 6.61-10.71, p < 0.00001, I
= 0%). And the treatment effect of PRP remained effective in long-term follow-up (Mean Difference = 7.83, 95% CI = 5.57-10.09, p = 0.46, I
= 0%). For VAS scores, PRP relieved patients' pain (Standardized Mean Difference=-0.62, 95%CI=-1.13-0.10, p = 0.02, I
= 77%) but showed a greater advantage in patients with cartilage injuries of the talus (Standardized Mean Difference=-1.24, 95%CI=-1.68-0.81, p < 0.00001, I
= 0%). Subgroup analyses according to different disease types and different follow-up times showed that PRP had significant efficacy in talar cartilage injuries in both the short and long term. A meta-analysis of single-arm studies showed that PRP was helpful in improving patients' pain before and after the intervention (Standardized Mean Difference = -1.76, 95% CI = -2.85 to -0.67, p = 0.002, I^2 = 87%).However, the high level of heterogeneity may be due to the large differences between the inclusion criteria of the single-arm studies.
More clinical studies are needed to further confirm the efficacy of platelet-rich plasma in ankle disorders, and the current study only suggests that platelet-rich plasma may be more effective in talus cartilage injuries than in other types of ankle disorders.</description><subject>Analysis</subject><subject>Ankle Joint</subject><subject>Care and treatment</subject><subject>Diseases</subject><subject>Humans</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Online databases</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - therapy</subject><subject>Pain</subject><subject>Platelet-Rich Plasma</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Systematic Review</subject><subject>Treatment Outcome</subject><issn>1749-799X</issn><issn>1749-799X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0Eou3CH-CALHHhYvBn4nBBVQUFqRKXInFAsmYn467BSZY4W7T_Hi9bqnIaW37m1Ywfxl4o-UYp37wtykjlhdRWSGe1FO4RO1Wt7UTbdd8ePzifsLNSfkjppPP2KTsxXWuVsfqUfb_eEKcYEwLu-RT5NsNCmRYxJ9wcbmUAnkYO489MvE-FoNA7Drzsy0IDLAn5TLeJflek5wMtIGCEvC-pPGNPIuRCz-_qin39-OH64pO4-nL5-eL8SqDyxoheOy37qF3XKK2kRIhGSbJakUWNsWnWZl0rektonInYS49eIvZO9dCaFXt_zN3u1gP1SOMyQw7bOQ0w78MEKfz_MqZNuJlug1KN71xnasLru4R5-rWjsoQhFaScYaRpV4JR9eu09nXeFXt1RG8gU0hjnGokHvBw7rXqXNNKXSl9pHCeSpkp3k-jZDjYC0d7odoLf-0FV5tePtzjvuWfLvMHWYCWIw</recordid><startdate>20241231</startdate><enddate>20241231</enddate><creator>Ding, Qixin</creator><creator>Wang, Xu</creator><creator>Liu, Yurong</creator><creator>Li, Yuefang</creator><creator>Zhang, Di</creator><creator>Wang, Heling</creator><creator>Ma, Shenhong</creator><creator>Han, Qiaohua</creator><creator>Zhuang, Weisheng</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241231</creationdate><title>The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis</title><author>Ding, Qixin ; Wang, Xu ; Liu, Yurong ; Li, Yuefang ; Zhang, Di ; Wang, Heling ; Ma, Shenhong ; Han, Qiaohua ; Zhuang, Weisheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1833-d2520df259612100caf310e421e4c2cf66b3b2cfc84ec353fcd08c80ccd51da73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Ankle Joint</topic><topic>Care and treatment</topic><topic>Diseases</topic><topic>Humans</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Online databases</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - therapy</topic><topic>Pain</topic><topic>Platelet-Rich Plasma</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Systematic Review</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ding, Qixin</creatorcontrib><creatorcontrib>Wang, Xu</creatorcontrib><creatorcontrib>Liu, Yurong</creatorcontrib><creatorcontrib>Li, Yuefang</creatorcontrib><creatorcontrib>Zhang, Di</creatorcontrib><creatorcontrib>Wang, Heling</creatorcontrib><creatorcontrib>Ma, Shenhong</creatorcontrib><creatorcontrib>Han, Qiaohua</creatorcontrib><creatorcontrib>Zhuang, Weisheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of orthopaedic surgery and research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ding, Qixin</au><au>Wang, Xu</au><au>Liu, Yurong</au><au>Li, Yuefang</au><au>Zhang, Di</au><au>Wang, Heling</au><au>Ma, Shenhong</au><au>Han, Qiaohua</au><au>Zhuang, Weisheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis</atitle><jtitle>Journal of orthopaedic surgery and research</jtitle><addtitle>J Orthop Surg Res</addtitle><date>2024-12-31</date><risdate>2024</risdate><volume>19</volume><issue>1</issue><spage>895</spage><pages>895-</pages><artnum>895</artnum><issn>1749-799X</issn><eissn>1749-799X</eissn><abstract>Ankle osteoarthritis is a debilitating condition that significantly impairs patients' quality of life. Platelet-rich plasma has emerged as a novel cellular therapy in clinical practice. This study evaluates the clinical efficacy of platelet-rich plasma (PRP) after intervention in ankle disorders, so as to provide strong evidence in support of clinical treatment.
A comprehensive and systematic search of PubMed, the Cochrane Library, Embase and web of science databases was performed, and studies that met the requirements according to the inclusion criteria were analyzed using Review Manager and STATA version 14.0. Quality assessment was performed using the Cochrane Collaboration Risk of Bias 2.0 tool. The outcome indicators were the American Orthopaedic Foot and Ankle Society Rating Scale (AOFAS) and Visual Analog Scale (VAS) scores used to evaluate the efficacy of platelet-rich plasma.
A total of 10 studies met the inclusion criteria. Regarding the AOFAS score, a meta-analysis that included five randomized controlled trials (each study extracted the score results at the last follow-up time) showed no statistically significant differences between the platelet-rich plasma intervention group and the control group, and there was a great deal of heterogeneity in the results, with subgroup analyses based on disease type. (Mean Difference = 4.14, 95% CI=-0.60-8.87, p = 0.09, I
= 86%). Subgroup analysis showed a more significant effect in patients with talar cartilage injuries (Mean Difference = 8.66, 95%CI = 6.61-10.71, p < 0.00001, I
= 0%). And the treatment effect of PRP remained effective in long-term follow-up (Mean Difference = 7.83, 95% CI = 5.57-10.09, p = 0.46, I
= 0%). For VAS scores, PRP relieved patients' pain (Standardized Mean Difference=-0.62, 95%CI=-1.13-0.10, p = 0.02, I
= 77%) but showed a greater advantage in patients with cartilage injuries of the talus (Standardized Mean Difference=-1.24, 95%CI=-1.68-0.81, p < 0.00001, I
= 0%). Subgroup analyses according to different disease types and different follow-up times showed that PRP had significant efficacy in talar cartilage injuries in both the short and long term. A meta-analysis of single-arm studies showed that PRP was helpful in improving patients' pain before and after the intervention (Standardized Mean Difference = -1.76, 95% CI = -2.85 to -0.67, p = 0.002, I^2 = 87%).However, the high level of heterogeneity may be due to the large differences between the inclusion criteria of the single-arm studies.
More clinical studies are needed to further confirm the efficacy of platelet-rich plasma in ankle disorders, and the current study only suggests that platelet-rich plasma may be more effective in talus cartilage injuries than in other types of ankle disorders.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39741342</pmid><doi>10.1186/s13018-024-05420-5</doi><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; Springer Nature OA Free Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; SpringerLink Journals - AutoHoldings |
| subjects | Analysis Ankle Joint Care and treatment Diseases Humans Medical research Medicine, Experimental Online databases Osteoarthritis Osteoarthritis - therapy Pain Platelet-Rich Plasma Randomized Controlled Trials as Topic Systematic Review Treatment Outcome |
| title | The efficacy of platelet-rich plasma in ankle disease: a systematic review and meta-analysis |
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