Incidence, Clinicopathological Features, and Outcomes of Signet Ring Colorectal Carcinoma: A Retrospective Study

Background Signet ring cell carcinoma (SRCC) is a rare subtype of colorectal cancer with significant variations in clinical characteristics and poor prognosis. However, there is limited data available in Pakistan. Therefore, we analyzed to examine the incidence, clinicopathological features, treatments, and outcomes of SRCC in colorectal cancer cases in Pakistan. Methods This study includes 214 primary signet ring cell carcinoma cases in the colon and rectum. All relevant clinical information extracts on demographic details, laboratory results, radiological findings, endoscopy, pathologic diagnoses, surgical interventions, neoadjuvant and adjuvant therapies, and their corresponding outcomes were undertaken from the same online database of hospital and analyzed using SPSS (SPSS Inc., Chicago, IL, USA), Chi-square test, and independent sample Kruskal-Wallis H test. Results The prevalence of SRCC was higher in younger patients (