Inflammation and hemostasis in loiasis before and after ivermectin treatment: A biological pilot cross-sectional study

We assessed the impact of loiasis and its treatment with ivermectin on hemostasis and inflammation in 38 adults in Cameroon. Participants were divided into four balanced groups based on their Loa loa microfilarial densities. At baseline, eosinophils and platelets increased with microfilarial densiti...

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Veröffentlicht in:	PLoS neglected tropical diseases 2024-12, Vol.18 (12), p.e0012491
Hauptverfasser:	Lepage, Tristan M, Nzune-Toche, Narcisse, Nkwengoua, Lucie A, Nana-Djeunga, Hugues C, Pion, Sebastien D S, Kamgno, Joseph, Boullé, Charlotte, Campillo, Jérémy T, Boussinesq, Michel, Tayou, Claude T, Chesnais, Cédric B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Antiparasitic Agents - therapeutic use Biology and Life Sciences C-reactive protein C-Reactive Protein - analysis Cameroon Cross-Sectional Studies Dosage and administration Drug therapy Eosinophils - drug effects Eosinophils - immunology Ethylenediaminetetraacetic acid Female Fibrin Fibrinogen Health aspects Hemostasis Hemostasis - drug effects Humans Inflammation Inflammation - drug therapy Ivermectin Ivermectin - therapeutic use Loa - drug effects Loiasis - drug therapy Male Medical research Medicine and Health Sciences Medicine, Experimental Middle Aged Parasitic diseases Physiological aspects Pilot Projects Young Adult
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Zusammenfassung:	We assessed the impact of loiasis and its treatment with ivermectin on hemostasis and inflammation in 38 adults in Cameroon. Participants were divided into four balanced groups based on their Loa loa microfilarial densities. At baseline, eosinophils and platelets increased with microfilarial densities (p
ISSN:	1935-2735 1935-2727 1935-2735
DOI:	10.1371/journal.pntd.0012491