Isolation and characterization of a sigB deletion mutant of Staphylococcus aureus

The sigB gene of Staphylococcus aureus, coding for the alternate sigma factor B, has been deleted by allelic replacement mutagenesis. The mutant grew as well as the parent in vitro, although it was deficient in clumping factor, coagulase, and pigment. In two murine and one rat infection model the mu...

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Veröffentlicht in:	Infection and immunity 1999-07, Vol.67 (7), p.3667-3669
Hauptverfasser:	NICHOLAS, R. O, TONG LI, MCDEVITT, D, MARRA, A, SUCOLOSKI, T. S, DEMARSH, P. L, GENTRY, D. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Proteins - genetics Bacteriology Biological and medical sciences clumping factor coagulase Fundamental and applied biological sciences. Psychology Gene Deletion Mice Microbiology Molecular and Cellular Pathogenesis Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Rats sigB gene Sigma Factor - genetics Staphylococcal Infections - microbiology Staphylococcus aureus Staphylococcus aureus - genetics Staphylococcus aureus - pathogenicity Virulence - genetics
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Beschreibung
Zusammenfassung:	The sigB gene of Staphylococcus aureus, coding for the alternate sigma factor B, has been deleted by allelic replacement mutagenesis. The mutant grew as well as the parent in vitro, although it was deficient in clumping factor, coagulase, and pigment. In two murine and one rat infection model the mutant showed no reduction in virulence.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/IAI.67.7.3667-3669.1999