Impact of exercise and fasting on mitochondrial regulators in human muscle

To investigate the impact of acute energetic stress (acute HIIE and fasting) on , , , , and in human skeletal muscle. The current study performed secondary analyses using muscle biopsy samples from two previously published studies: study 1) leg muscle biopsies from nine men and eight women were obtained pre and 3 h following acute high-intensity interval cycling exercise (HIIE); study 2) leg muscle biopsies were obtained from nine men pre-, during, and post-an 8 h fast with or without 2 h of arm ergometer exercise. RT-PCR was performed on samples from each study to determine the mRNA expression of , , , , and . Additionally, we retrieved data from meta-analyzed human muscle gene expression using the publicly available database MetaMex. (p