Gram-Negative Colonization and Bacterial Translocation Drive Neonatal Sepsis in the Indian Setting

Gram-Negative Colonization and Bacterial Translocation Drive Neonatal Sepsis in the Indian Setting

Background The gut microbiota, comprising billions of microorganisms, plays a pivotal role in health and disease. This study aims to investigate the effect of sepsis on gut microbiome of neonates admitted to the Neonatal Intensive Care Unit. Methods A prospective cohort study was carried out in the...

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Veröffentlicht in:Journal of Epidemiology and Global Health 2024-12, Vol.14 (4), p.1525-1535
Hauptverfasser: Iqbal, Faiza, Barche, Apurv, Shenoy, Padmaja A., Lewis, Leslie Edward S., Purkayastha, Jayashree, Vandana, K. E.
Format: Artikel
Sprache:eng
Schlagworte:
Bacteria
Bacterial Translocation
Birth weight
Blood culture
Digestive system
Drug resistance
Dysbacteriosis
Dysbiosis
Enterocolitis
Feces - microbiology
Female
Gastrointestinal Microbiome - physiology
Gastrointestinal tract
Gestational age
Gram-Negative Bacteria - isolation & purification
Gram-Negative Bacterial Infections - diagnosis
Gram-Negative Bacterial Infections - epidemiology
Gram-Negative Bacterial Infections - microbiology
Gut microbiome
Humans
India - epidemiology
Infant, Newborn
Infant, Premature
Intensive Care Units, Neonatal - statistics & numerical data
Intestinal microflora
Male
Medicine
Medicine & Public Health
Microbial colonization
Microbiomes
Microbiota
Microorganisms
Necrotizing enterocolitis
Neonatal sepsis
Neonatal Sepsis - diagnosis
Neonatal Sepsis - epidemiology
Neonatal Sepsis - microbiology
Neonates
Population studies
Preterm infants
Probiotics
Prospective Studies
Proteobacteria
Research Article
Sepsis
Translocation
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Zusammenfassung:Background The gut microbiota, comprising billions of microorganisms, plays a pivotal role in health and disease. This study aims to investigate the effect of sepsis on gut microbiome of neonates admitted to the Neonatal Intensive Care Unit. Methods A prospective cohort study was carried out in the NICU of tertiary care hospital in Karnataka, India, from January 2021 to September 2023. Preterm neonates with birth weight 
ISSN:2210-6014
2210-6006
2210-6014
DOI:10.1007/s44197-024-00303-8