Association between magnesium and vitamin D status in adults with high prevalence of vitamin D deficiency and insufficiency

Purpose It has been assumed that magnesium (Mg) status may interact with vitamin D status. We therefore aimed at investigating the association between Mg and vitamin D status in a large cohort of adult individuals with a high prevalence of deficient/insufficient vitamin D and Mg status. Methods We used data from the Ludwigshafen Risk and Cardiovascular Health Study ( n = 2,286) to analyze differences according to serum Mg status in circulating 25-hydroxyvitamin D [25(OH)D] (primary endpoint), 24,25-dihydroxyvitamin D 3 [24,25(OH) 2 D 3 ], vitamin D metabolite ratio and calcitriol, and odds ratios for deficient or insufficient 25(OH)D (secondary endpoints). We performed unadjusted and risk score (RS) adjusted and matched analyses. Results Of the study cohort (average age > 60 years), one third was 25(OH)D deficient (