3-oxo acid coenzyme A-transferase in normal and diabetic rat muscle

The amounts of succinyl-CoA--3-oxo acid CoA-transferase (EC 2.8.3.5) decrease progressively in skeletal muscle in streptozotocin-diabetic rats, reaching after 10 days about 50% of the value in normal rat muscle. Electrofocusing studies indicate the occurrence of partial proteolysis of the enzyme in...

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Veröffentlicht in:	Biochemical journal 1976-08, Vol.158 (2), p.509-512
Hauptverfasser:	Fenselau, A, Wallis, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetoacetates - metabolism Animals Diabetes Mellitus - chemically induced Diabetes Mellitus - enzymology Female Isoelectric Focusing Kinetics Mitochondria, Muscle - metabolism Muscles - enzymology Rats Starvation Streptozocin Sulfurtransferases - metabolism Time Factors
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Zusammenfassung:	The amounts of succinyl-CoA--3-oxo acid CoA-transferase (EC 2.8.3.5) decrease progressively in skeletal muscle in streptozotocin-diabetic rats, reaching after 10 days about 50% of the value in normal rat muscle. Electrofocusing studies indicate the occurrence of partial proteolysis of the enzyme in diabetic muscle. However, several functional parameters relating to acetoacetate utilization, including substrate inhibition, are quite similar for muscle transferase preparations from normal and diseased rats. The development of pathological ketoacidosis is discussed in the light of these observations.
ISSN:	0264-6021 0306-3283 1470-8728
DOI:	10.1042/bj1580509