Long‐Range Proton Channels Constructed via Hierarchical Peptide Self‐Assembly
The quest to understand and mimic proton translocation mechanisms in natural channels has driven the development of peptide‐based artificial channels facilitating efficient proton transport across nanometric membranes. It is demonstrated here that hierarchical peptide self‐assembly can form micromet...
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Veröffentlicht in: | Advanced materials (Weinheim) 2024-11, Vol.36 (50), p.e2409248-n/a |
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Zusammenfassung: | The quest to understand and mimic proton translocation mechanisms in natural channels has driven the development of peptide‐based artificial channels facilitating efficient proton transport across nanometric membranes. It is demonstrated here that hierarchical peptide self‐assembly can form micrometers‐long proton nanochannels. The fourfold symmetrical peptide design leverages intermolecular aromatic interactions to align self‐assembled cyclic peptide nanotubes, creating hydrophilic nanochannels between them. Titratable amino acid sidechains are positioned adjacent to each other within the channels, enabling the formation of hydrogen‐bonded chains upon hydration, and facilitating efficient proton transport. Moreover, these chains are enriched with protons and water molecules by interacting with immobile counter ions introduced into the channels, increasing proton flow density and rate. This system maintains proton transfer rates closely resembling those in natural protein channels over micrometer distances. The functional behavior of these inherently recyclable and biocompatible systems opens the door for their exploitation in diverse applications in energy storage and conversion, biomedicine, and bioelectronics.
The authors present proton nanochannels prepared by hierarchical self‐assembly of cyclic peptides with transfer rates closely matching those of natural protein channels while maintaining transport over microns. Proton density is controlled by a counter ion doping effect. The span of proton transport allows for their use in energy solutions, biomedicine, and bioelectronics. |
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ISSN: | 0935-9648 1521-4095 1521-4095 |
DOI: | 10.1002/adma.202409248 |