Predictors of distant metastatic recurrence in head and neck cutaneous squamous cell carcinoma with lymph node metastases treated with curative intent: A multicenter study

Background We aimed to identify predictors of distant metastatic recurrence (DMR) in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) with nodal metastases treated with curative intent. Methods Predictors of DMR were identified using Cox regression in a multicenter study of 115...

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Veröffentlicht in:	Head & neck 2025-01, Vol.47 (1), p.254-262
Hauptverfasser:	Ebrahimi, Ardalan, Gupta, Ruta, McDowell, Lachlan, Magarey, Matthew J. R., Smith, Paul N., Schulte, Klaus‐Martin, Perriman, Diana M., Veness, Michael, Porceddu, Sandro, Low, Tsu‐Hui Hubert, Fowler, Allan, Clark, Jonathan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - therapy cutaneous squamous cell carcinoma distant metastases Female Head & neck cancer head and neck cancer Head and neck carcinoma Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans Immunosuppression lymph node metastasis Lymph nodes Lymphatic Metastasis Male Metastases Middle Aged Multivariate analysis Neoplasm Recurrence, Local - pathology Original Prognosis Proportional Hazards Models Retrospective Studies Risk Factors Skin Neoplasms - mortality Skin Neoplasms - pathology Skin Neoplasms - therapy Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - mortality Squamous Cell Carcinoma of Head and Neck - pathology Squamous Cell Carcinoma of Head and Neck - secondary Squamous Cell Carcinoma of Head and Neck - therapy
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Zusammenfassung:	Background We aimed to identify predictors of distant metastatic recurrence (DMR) in patients with head and neck cutaneous squamous cell carcinoma (HNcSCC) with nodal metastases treated with curative intent. Methods Predictors of DMR were identified using Cox regression in a multicenter study of 1151 patients. Results The 5‐year risk of DMR was 9.6%. On multivariate analysis, immunosuppression (HR 2.93; 95% CI: 1.70–5.05; p 6 cm [versus ≤3 cm (HR 2.77; 95% CI: 1.09–7.03; p = 0.032)], ≥5 nodal metastases [versus 1–2 (HR 2.79; 95% CI: 1.63–4.78; p
ISSN:	1043-3074 1097-0347 1097-0347
DOI:	10.1002/hed.27912