Role of Autophagy in Type 2 Diabetes Mellitus: The Metabolic Clash

ABSTRACT Type 2 diabetes mellitus (T2DM) is developed due to the development of insulin resistance (IR) and pancreatic β cell dysfunction with subsequent hyperglycaemia. Hyperglycaemia‐induced oxidative stress and endoplasmic reticulum (ER) stress enhances inflammatory disorders, leading to further...

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Veröffentlicht in:	Journal of cellular and molecular medicine 2024-12, Vol.28 (23), p.e70240-n/a
Hauptverfasser:	Alanazi, Yousef Abud, Al‐kuraishy, Haydar M., Al‐Gareeb, Ali I., Alexiou, Athanasios, Papadakis, Marios, Bahaa, Mostafa M., Negm, Walaa A., AlAnazi, Faisal Holil, Alrouji, Mohammed, Batiha, Gaber El‐Saber
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autophagy Beta cells Body fat Cell activation Cell death Cytokines Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Endoplasmic reticulum Endoplasmic Reticulum Stress Ferroptosis Homeostasis Humans Hyperglycemia Hyperglycemia - metabolism Hyperglycemia - pathology Inflammation Inflammatory diseases Insulin Resistance Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Kinases Metabolic disorders Organelles Oxidative Stress Pancreas pancreatic β cell Pathogenesis Pathogens Proteins Review type 2 diabetes mellitus Viral infections
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Zusammenfassung:	ABSTRACT Type 2 diabetes mellitus (T2DM) is developed due to the development of insulin resistance (IR) and pancreatic β cell dysfunction with subsequent hyperglycaemia. Hyperglycaemia‐induced oxidative stress and endoplasmic reticulum (ER) stress enhances inflammatory disorders, leading to further pancreatic β cell dysfunction. These changes trigger autophagy activation, which recycles cytoplasmic components and injured organelles. Autophagy regulates pancreatic β cell functions by different mechanisms. Though the exact role of autophagy in T2DM is not completely elucidated, that could be beneficial or detrimental. Therefore, this review aims to discuss the exact role of autophagy in the pathogenesis of T2DM.
ISSN:	1582-1838 1582-4934 1582-4934
DOI:	10.1111/jcmm.70240