Development and validation of machine learning models for intraoperative blood transfusion prediction in severe lumbar disc herniation

Lumbar disc herniation (LDH) is a common cause of lower back pain and sciatica, and posterior lumbar interbody fusion (PLIF) is always employed. This multicenter retrospective study investigates predicting intraoperative blood transfusion for LDH patients undergoing PLIF in China. The research includes 6,241 patients from 22 medical centers and employs 8 feature selection methods and 10 machine learning models, including an integrated stacking model. The optimal predictive model was selected based on the receiver operating characteristic area under the curve, clinical applicability, and computational efficiency. Among the evaluated combinations, the simulated annealing support vector machine recursive + stacking model achieved the highest performance with an area under the curve of 0.884, supported by robust calibration and decision curve analyses. A publicly accessible web calculator was developed to assist clinicians in decision-making. This work significantly enhances intraoperative transfusion predictions, providing valuable tools for improving patient management. [Display omitted] •A nationwide registered multicenter study with over 6000 patients from 22 hospitals•Comprehensive machine learning approaches to predict blood transfusion requirements•Construction of a web calculator to aid the clinical decision-making process•Proactively manage resources and optimize patient outcomes with the novel model Health sciences; Natural sciences; Computer science