Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden
Objective Assess the impact of obstructive sleep apnea (OSA) on chronic rhinosinusitis (CRS) severeity. Study Design Retrospective database review. Setting TriNetX US database. Methods TriNetX US Collaborative Network database was queried for cohorts of patients with OSA, CRS, and CRS with comorbid...
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| Veröffentlicht in: | Otolaryngology-head and neck surgery 2024-12, Vol.171 (6), p.1879-1886 |
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| creator | Garvey, Emily Duffy, Alexander Tekumalla, Sruti Naimi, Bita Kahn, Chase Yang, Angela Urdang, Zachary Farquhar, Douglas Rosen, Marc Nyquist, Gurston G. Toskala, Elina Rabinowitz, Mindy |
| description | Objective
Assess the impact of obstructive sleep apnea (OSA) on chronic rhinosinusitis (CRS) severeity.
Study Design
Retrospective database review.
Setting
TriNetX US database.
Methods
TriNetX US Collaborative Network database was queried for cohorts of patients with OSA, CRS, and CRS with comorbid OSA (CRS‐OSA). Data included demographics, CRS severity was assessed via rates of endoscopic sinus surgery (ESS), antibiotic, and oral steroid use. Propensity score matching was performed to account for differences in demographics and clinical variables.
Results
The query identified 1,818,879 patients with CRS, 481144 with OSA, and 93,153 CRS‐OSA patients. OSA‐CRS patients had higher rates of hypertension, diabetes mellitus, obesity, and asthma than either CRS or OSA populations (P |
| doi_str_mv | 10.1002/ohn.934 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11605011</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3131853793</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2984-fb2785f415199338ccf5e57e06615ce33c750b42c4bb2b5655a1be9997439a353</originalsourceid><addsrcrecordid>eNp1kdFO2zAYRq2JaXRl4g0m34E0Bew4juPdoK6DgYSoRNdry3H_EKPUDnbC1LfZs_BkpCpUcMGVL3x0_k86CB1SckIJSU997U4kyz6hESVSJHlBxR4aESqzhEtZ7KOvMd4TQvJciC9on0kuOBdyhO5nZexCbzr7CHjeALR40jrQWLslntbBO2vwbW2dj9b10XY2_sQLt4QQuwGx7g53NeCrVatNh32FZ_MJ9g5Pb-dP_3_bCDoC_tWHJbgD9LnSTYRvL-8YLS7O_04vk-vZn6vp5DoxqSyypCpTUfAqo5xKyVhhTMWBCxi2U26AMSM4KbPUZGWZljznXNMSpJQiY1IzzsbobOtt-3IFSwOuC7pRbbArHdbKa6ve_zhbqzv_qCjNCSeUDobjF0PwDz3ETq1sNNA02oHvo2KU0YIzMcwbo6MtaoKPMUC1u0OJ2qRRQxo1pBnI729n7bjXFgPwYwv8sw2sP_Ko2eXNRvcMjcCYrA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3131853793</pqid></control><display><type>article</type><title>Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden</title><source>MEDLINE</source><source>Wiley Blackwell Single Titles</source><creator>Garvey, Emily ; Duffy, Alexander ; Tekumalla, Sruti ; Naimi, Bita ; Kahn, Chase ; Yang, Angela ; Urdang, Zachary ; Farquhar, Douglas ; Rosen, Marc ; Nyquist, Gurston G. ; Toskala, Elina ; Rabinowitz, Mindy</creator><creatorcontrib>Garvey, Emily ; Duffy, Alexander ; Tekumalla, Sruti ; Naimi, Bita ; Kahn, Chase ; Yang, Angela ; Urdang, Zachary ; Farquhar, Douglas ; Rosen, Marc ; Nyquist, Gurston G. ; Toskala, Elina ; Rabinowitz, Mindy</creatorcontrib><description><![CDATA[Objective
Assess the impact of obstructive sleep apnea (OSA) on chronic rhinosinusitis (CRS) severeity.
Study Design
Retrospective database review.
Setting
TriNetX US database.
Methods
TriNetX US Collaborative Network database was queried for cohorts of patients with OSA, CRS, and CRS with comorbid OSA (CRS‐OSA). Data included demographics, CRS severity was assessed via rates of endoscopic sinus surgery (ESS), antibiotic, and oral steroid use. Propensity score matching was performed to account for differences in demographics and clinical variables.
Results
The query identified 1,818,879 patients with CRS, 481144 with OSA, and 93,153 CRS‐OSA patients. OSA‐CRS patients had higher rates of hypertension, diabetes mellitus, obesity, and asthma than either CRS or OSA populations (P < 0.0001). CRS‐OSA patients demonstrated higher rates of ESS (odds ratio [OR]: 1.91, 1.82‐2.02, P < 0.0001), antibiotic (OR: 1.90, 1.81‐1.96, P < 0.001), and oral steroid use (OR: 2.23, 2.16‐2.28, P < 0.001) compared to CRS‐only patients. CRS‐OSA patients not on continuous positive airway pressure had higher utilization of antibiotics (OR: 3.24, 2.82‐3.71, P < 0.0001) and steroids (OR: 2.28, 2.05‐2.55, P < 0.0001) than nonutilizers. CRS‐OSA patients with sleep‐related surgical interventions required fewer antibiotic courses (OR: 1.93, 1.62‐2.28, P < 0.0001).
Conclusion
CRS‐OSA patients experience higher rates of comorbidities associated with both diseases than those with CRS or OSA alone. OSA was associated with an increased risk of ESS, antibiotic, and steroid use in patients with CRS. There appears to be a correlation with treatment of OSA and CRS outcomes, however, further studies are required.]]></description><identifier>ISSN: 0194-5998</identifier><identifier>ISSN: 1097-6817</identifier><identifier>EISSN: 1097-6817</identifier><identifier>DOI: 10.1002/ohn.934</identifier><identifier>PMID: 39575579</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Adult ; Aged ; Chronic Disease ; chronic rhinosinusitis ; Cost of Illness ; Databases, Factual ; Female ; Humans ; Male ; Middle Aged ; obstructive sleep apnea ; Original Research ; quality of life ; Retrospective Studies ; Rhinitis - complications ; Rhinosinusitis ; Severity of Illness Index ; Sinusitis - complications ; Sleep Apnea, Obstructive - complications ; Sleep Apnea, Obstructive - epidemiology ; United States - epidemiology</subject><ispartof>Otolaryngology-head and neck surgery, 2024-12, Vol.171 (6), p.1879-1886</ispartof><rights>2024 The Author(s). Otolaryngology‐Head and Neck Surgery published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngology‐Head and Neck Surgery Foundation.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2984-fb2785f415199338ccf5e57e06615ce33c750b42c4bb2b5655a1be9997439a353</cites><orcidid>0000-0003-2497-4232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fohn.934$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fohn.934$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39575579$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Garvey, Emily</creatorcontrib><creatorcontrib>Duffy, Alexander</creatorcontrib><creatorcontrib>Tekumalla, Sruti</creatorcontrib><creatorcontrib>Naimi, Bita</creatorcontrib><creatorcontrib>Kahn, Chase</creatorcontrib><creatorcontrib>Yang, Angela</creatorcontrib><creatorcontrib>Urdang, Zachary</creatorcontrib><creatorcontrib>Farquhar, Douglas</creatorcontrib><creatorcontrib>Rosen, Marc</creatorcontrib><creatorcontrib>Nyquist, Gurston G.</creatorcontrib><creatorcontrib>Toskala, Elina</creatorcontrib><creatorcontrib>Rabinowitz, Mindy</creatorcontrib><title>Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden</title><title>Otolaryngology-head and neck surgery</title><addtitle>Otolaryngol Head Neck Surg</addtitle><description><![CDATA[Objective
Assess the impact of obstructive sleep apnea (OSA) on chronic rhinosinusitis (CRS) severeity.
Study Design
Retrospective database review.
Setting
TriNetX US database.
Methods
TriNetX US Collaborative Network database was queried for cohorts of patients with OSA, CRS, and CRS with comorbid OSA (CRS‐OSA). Data included demographics, CRS severity was assessed via rates of endoscopic sinus surgery (ESS), antibiotic, and oral steroid use. Propensity score matching was performed to account for differences in demographics and clinical variables.
Results
The query identified 1,818,879 patients with CRS, 481144 with OSA, and 93,153 CRS‐OSA patients. OSA‐CRS patients had higher rates of hypertension, diabetes mellitus, obesity, and asthma than either CRS or OSA populations (P < 0.0001). CRS‐OSA patients demonstrated higher rates of ESS (odds ratio [OR]: 1.91, 1.82‐2.02, P < 0.0001), antibiotic (OR: 1.90, 1.81‐1.96, P < 0.001), and oral steroid use (OR: 2.23, 2.16‐2.28, P < 0.001) compared to CRS‐only patients. CRS‐OSA patients not on continuous positive airway pressure had higher utilization of antibiotics (OR: 3.24, 2.82‐3.71, P < 0.0001) and steroids (OR: 2.28, 2.05‐2.55, P < 0.0001) than nonutilizers. CRS‐OSA patients with sleep‐related surgical interventions required fewer antibiotic courses (OR: 1.93, 1.62‐2.28, P < 0.0001).
Conclusion
CRS‐OSA patients experience higher rates of comorbidities associated with both diseases than those with CRS or OSA alone. OSA was associated with an increased risk of ESS, antibiotic, and steroid use in patients with CRS. There appears to be a correlation with treatment of OSA and CRS outcomes, however, further studies are required.]]></description><subject>Adult</subject><subject>Aged</subject><subject>Chronic Disease</subject><subject>chronic rhinosinusitis</subject><subject>Cost of Illness</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>obstructive sleep apnea</subject><subject>Original Research</subject><subject>quality of life</subject><subject>Retrospective Studies</subject><subject>Rhinitis - complications</subject><subject>Rhinosinusitis</subject><subject>Severity of Illness Index</subject><subject>Sinusitis - complications</subject><subject>Sleep Apnea, Obstructive - complications</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>United States - epidemiology</subject><issn>0194-5998</issn><issn>1097-6817</issn><issn>1097-6817</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp1kdFO2zAYRq2JaXRl4g0m34E0Bew4juPdoK6DgYSoRNdry3H_EKPUDnbC1LfZs_BkpCpUcMGVL3x0_k86CB1SckIJSU997U4kyz6hESVSJHlBxR4aESqzhEtZ7KOvMd4TQvJciC9on0kuOBdyhO5nZexCbzr7CHjeALR40jrQWLslntbBO2vwbW2dj9b10XY2_sQLt4QQuwGx7g53NeCrVatNh32FZ_MJ9g5Pb-dP_3_bCDoC_tWHJbgD9LnSTYRvL-8YLS7O_04vk-vZn6vp5DoxqSyypCpTUfAqo5xKyVhhTMWBCxi2U26AMSM4KbPUZGWZljznXNMSpJQiY1IzzsbobOtt-3IFSwOuC7pRbbArHdbKa6ve_zhbqzv_qCjNCSeUDobjF0PwDz3ETq1sNNA02oHvo2KU0YIzMcwbo6MtaoKPMUC1u0OJ2qRRQxo1pBnI729n7bjXFgPwYwv8sw2sP_Ko2eXNRvcMjcCYrA</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Garvey, Emily</creator><creator>Duffy, Alexander</creator><creator>Tekumalla, Sruti</creator><creator>Naimi, Bita</creator><creator>Kahn, Chase</creator><creator>Yang, Angela</creator><creator>Urdang, Zachary</creator><creator>Farquhar, Douglas</creator><creator>Rosen, Marc</creator><creator>Nyquist, Gurston G.</creator><creator>Toskala, Elina</creator><creator>Rabinowitz, Mindy</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2497-4232</orcidid></search><sort><creationdate>202412</creationdate><title>Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden</title><author>Garvey, Emily ; Duffy, Alexander ; Tekumalla, Sruti ; Naimi, Bita ; Kahn, Chase ; Yang, Angela ; Urdang, Zachary ; Farquhar, Douglas ; Rosen, Marc ; Nyquist, Gurston G. ; Toskala, Elina ; Rabinowitz, Mindy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2984-fb2785f415199338ccf5e57e06615ce33c750b42c4bb2b5655a1be9997439a353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Chronic Disease</topic><topic>chronic rhinosinusitis</topic><topic>Cost of Illness</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>obstructive sleep apnea</topic><topic>Original Research</topic><topic>quality of life</topic><topic>Retrospective Studies</topic><topic>Rhinitis - complications</topic><topic>Rhinosinusitis</topic><topic>Severity of Illness Index</topic><topic>Sinusitis - complications</topic><topic>Sleep Apnea, Obstructive - complications</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Garvey, Emily</creatorcontrib><creatorcontrib>Duffy, Alexander</creatorcontrib><creatorcontrib>Tekumalla, Sruti</creatorcontrib><creatorcontrib>Naimi, Bita</creatorcontrib><creatorcontrib>Kahn, Chase</creatorcontrib><creatorcontrib>Yang, Angela</creatorcontrib><creatorcontrib>Urdang, Zachary</creatorcontrib><creatorcontrib>Farquhar, Douglas</creatorcontrib><creatorcontrib>Rosen, Marc</creatorcontrib><creatorcontrib>Nyquist, Gurston G.</creatorcontrib><creatorcontrib>Toskala, Elina</creatorcontrib><creatorcontrib>Rabinowitz, Mindy</creatorcontrib><collection>Wiley Online Library</collection><collection>Wiley-Blackwell Free Backfiles(OpenAccess)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Otolaryngology-head and neck surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Garvey, Emily</au><au>Duffy, Alexander</au><au>Tekumalla, Sruti</au><au>Naimi, Bita</au><au>Kahn, Chase</au><au>Yang, Angela</au><au>Urdang, Zachary</au><au>Farquhar, Douglas</au><au>Rosen, Marc</au><au>Nyquist, Gurston G.</au><au>Toskala, Elina</au><au>Rabinowitz, Mindy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden</atitle><jtitle>Otolaryngology-head and neck surgery</jtitle><addtitle>Otolaryngol Head Neck Surg</addtitle><date>2024-12</date><risdate>2024</risdate><volume>171</volume><issue>6</issue><spage>1879</spage><epage>1886</epage><pages>1879-1886</pages><issn>0194-5998</issn><issn>1097-6817</issn><eissn>1097-6817</eissn><abstract><![CDATA[Objective
Assess the impact of obstructive sleep apnea (OSA) on chronic rhinosinusitis (CRS) severeity.
Study Design
Retrospective database review.
Setting
TriNetX US database.
Methods
TriNetX US Collaborative Network database was queried for cohorts of patients with OSA, CRS, and CRS with comorbid OSA (CRS‐OSA). Data included demographics, CRS severity was assessed via rates of endoscopic sinus surgery (ESS), antibiotic, and oral steroid use. Propensity score matching was performed to account for differences in demographics and clinical variables.
Results
The query identified 1,818,879 patients with CRS, 481144 with OSA, and 93,153 CRS‐OSA patients. OSA‐CRS patients had higher rates of hypertension, diabetes mellitus, obesity, and asthma than either CRS or OSA populations (P < 0.0001). CRS‐OSA patients demonstrated higher rates of ESS (odds ratio [OR]: 1.91, 1.82‐2.02, P < 0.0001), antibiotic (OR: 1.90, 1.81‐1.96, P < 0.001), and oral steroid use (OR: 2.23, 2.16‐2.28, P < 0.001) compared to CRS‐only patients. CRS‐OSA patients not on continuous positive airway pressure had higher utilization of antibiotics (OR: 3.24, 2.82‐3.71, P < 0.0001) and steroids (OR: 2.28, 2.05‐2.55, P < 0.0001) than nonutilizers. CRS‐OSA patients with sleep‐related surgical interventions required fewer antibiotic courses (OR: 1.93, 1.62‐2.28, P < 0.0001).
Conclusion
CRS‐OSA patients experience higher rates of comorbidities associated with both diseases than those with CRS or OSA alone. OSA was associated with an increased risk of ESS, antibiotic, and steroid use in patients with CRS. There appears to be a correlation with treatment of OSA and CRS outcomes, however, further studies are required.]]></abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>39575579</pmid><doi>10.1002/ohn.934</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2497-4232</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0194-5998 |
| ispartof | Otolaryngology-head and neck surgery, 2024-12, Vol.171 (6), p.1879-1886 |
| issn | 0194-5998 1097-6817 1097-6817 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11605011 |
| source | MEDLINE; Wiley Blackwell Single Titles |
| subjects | Adult Aged Chronic Disease chronic rhinosinusitis Cost of Illness Databases, Factual Female Humans Male Middle Aged obstructive sleep apnea Original Research quality of life Retrospective Studies Rhinitis - complications Rhinosinusitis Severity of Illness Index Sinusitis - complications Sleep Apnea, Obstructive - complications Sleep Apnea, Obstructive - epidemiology United States - epidemiology |
| title | Obstructive Sleep Apnea and Chronic Rhinosinusitis: Understanding the Impact of OSA on CRS Disease Burden |
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