TCF1 dosage determines cell fate during T cell development

Loss-of-function studies have shown that transcription factor T cell factor-1 (TCF1), encoded by the gene, is essential for T cell development in the thymus. We discovered that the expression level is regulated by E box DNA binding proteins, independent of Notch, and regulates αβ and γδ T cell devel...

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Veröffentlicht in:	Science advances 2024-11, Vol.10 (48), p.eado5982
Hauptverfasser:	Verma, Anjali, Aylward, Bridget, Ma, Fei, Sherman, Cheryl A, Chopp, Laura, Shinton, Susan, Roy, Roshni, Fahl, Shawn, Contreras, Alejandra, Koenitzer, Byron, Awasthi, Parirokh, Mazan-Mamczarz, Krystyna, De, Supriyo, Ollikainen, Noah, Qiu, Xiang, Bosselut, Remy, Sen, Ranjan, Wiest, David L, Sen, Jyoti Misra
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomedicine and Life Sciences Cell Differentiation Cell Lineage - genetics Enhancer Elements, Genetic Gene Dosage Hepatocyte Nuclear Factor 1-alpha - genetics Hepatocyte Nuclear Factor 1-alpha - metabolism Immunology Mice Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - metabolism SciAdv r-articles T Cell Transcription Factor 1 - genetics T Cell Transcription Factor 1 - metabolism T-Lymphocytes - cytology T-Lymphocytes - metabolism Thymus Gland - cytology Thymus Gland - metabolism
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