Causal effect of primary sclerosing cholangitis on diffuse large B-cell lymphoma: A two-sample Mendelian randomized study

The connection between Primary sclerosing cholangitis (PSC) and lymphoma remains uncertain. To address this, Mendelian randomization (MR) was utilized to investigate the potential causal links between PSC and lymphoma. A 2-sample MR analysis was conducted utilizing summary-level data obtained from genome-wide association study datasets. Four complementary MR methods were performed, including inverse-variance weighting (IVW), MR-Egger, weighted median, and MR-robust adjusted profile score (MR-RAPS). Several sensitivity analyses were also employed to further validate the results. The results of IVW estimates showed that there was a potential causal association between PSC and diffuse large B-cell lymphoma (DLBCL) risk (OR = 1.138, 95% CI = 1.052-1.230, P = .001). No causal association was observed between PSC and other lymphoma subtypes. No horizontal and directional pleiotropy was observed in the MR studies. This study represents the inaugural utilization of MR analysis to investigate the causal associations between PSC and DLBCL. Further investigation is warranted to elucidate the underlying mechanism of this causal relationship.