Sacubitril/Valsartan in Pediatric Heart Failure (PANORAMA-HF): A Randomized, Multicenter, Double-Blind Trial

Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is an established treatment for heart failure (HF) with reduced left ventricular ejection fraction. It has not been rigorously compared with angiotensin-converting enzyme inhibitors in children. PANORAMA-HF (Prospective Trial...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2024-11, Vol.150 (22), p.1756-1766
Hauptverfasser:	Shaddy, Robert, Burch, Michael, Kantor, Paul F, Solar-Yohay, Susan, Garito, Tania, Zhang, Sijia, Kocun, Michele, Mao, Chad, Cilliers, Antoinette, Wang, Xu, Canter, Charles, Rossano, Joseph, Wallis, Gonzalo, Menteer, Jondavid, Daou, Linda, Kusa, Jacek, Tokel, Kursat, Dilber, Daniel, Xu, Zhuoming, Xiao, Tingting, Halnon, Nancy, Daly, Kevin P, Bock, Matthew J, Zuckerman, Warren, Singh, Tajinder P, Chakrabarti, Manisha, Levitas, Aviva, Senni, Michele, Grutter, Giorgia, Kim, Gi Beom, Song, Jinyoung, Lee, Hyoung Doo, Chen, Ching Kit, Sanchez-de-Toledo, Joan, Law, Yuk, Wanitkun, Suthep, Cui, Yanqin, Anjos, Rui, Mese, Timur, Bonnet, Damien
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Aminobutyrates - adverse effects Aminobutyrates - therapeutic use Angiotensin Receptor Antagonists - therapeutic use Angiotensin-Converting Enzyme Inhibitors - therapeutic use Biphenyl Compounds - therapeutic use Child Child, Preschool Double-Blind Method Drug Combinations Enalapril - therapeutic use Female Heart Failure - drug therapy Heart Failure - physiopathology Humans Infant Male Natriuretic Peptide, Brain - blood Neprilysin - antagonists & inhibitors Original s Peptide Fragments - blood Prospective Studies Stroke Volume - drug effects Tetrazoles - adverse effects Tetrazoles - therapeutic use Treatment Outcome Valsartan Ventricular Dysfunction, Left - drug therapy Ventricular Dysfunction, Left - physiopathology
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Zusammenfassung:	Sacubitril/valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI), is an established treatment for heart failure (HF) with reduced left ventricular ejection fraction. It has not been rigorously compared with angiotensin-converting enzyme inhibitors in children. PANORAMA-HF (Prospective Trial to Assess the Angiotensin Receptor Blocker Neprilysin Inhibitor LCZ696 Versus Angiotensin-Converting Enzyme Inhibitor for the Medical Treatment of Pediatric HF) is a randomized, double-blind trial that evaluated the pharmacokinetics and pharmacodynamics (PK/PD), safety, and efficacy of sacubitril/valsartan versus enalapril in children 1 month to
ISSN:	0009-7322 1524-4539 1524-4539
DOI:	10.1161/CIRCULATIONAHA.123.066605