Searching for Immunocompromising Conditions in Low-risk Adults After Invasive Pneumococcal Disease: An Opportunity to Uncover Multiple Myeloma Early

Abstract There is a paucity of data on the prevalence of newly diagnosed immunosuppressive conditions following a first invasive pneumococcal infection (IPI) in adults considered to be at low risk for it. A total of 352 IPIs were reviewed over a 7-year period, with 39 (11.1%) ultimately analyzed. A 3.4-year follow-up period revealed that 4 patients (10.3%) had been diagnosed with immunosuppressive conditions. Of these, 3 had been diagnosed with multiple myeloma (MM). These findings indicate that in adults who experience a first IPI and are at low risk for it, MM should be strongly considered and addressed as early as possible.