Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice

Fndc5 is translated from an upstream ATG start codon and cleaved to produce irisin myokine precursor protein in humans and mice

Witmer et al. provide genomic and molecular evidence to demonstrate that Fndc5 (irisin myokine precursor protein) is translated in humans from an overlooked upstream ATG codon.

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Bibliographische Detailangaben
Veröffentlicht in:Cell metabolism 2024-05, Vol.36 (5), p.879-881
Hauptverfasser: Witmer, Nathan H., Linzer, Connor R., Boudreau, Ryan L.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Codon, Initiator - genetics
Fibronectins - genetics
Fibronectins - metabolism
Humans
Mice
Myokines
Protein Biosynthesis
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Beschreibung
Zusammenfassung:Witmer et al. provide genomic and molecular evidence to demonstrate that Fndc5 (irisin myokine precursor protein) is translated in humans from an overlooked upstream ATG codon.
ISSN:1550-4131
1932-7420
1932-7420
DOI:10.1016/j.cmet.2024.02.008