Region-Based Analyses of Existing Genome-Wide Association Studies Identifies Novel Potential Genetic Susceptibility Regions for Glioma

Further investigation of the potential susceptibility regions identified in our study may lead to a better understanding of glioma genetic risk and the underlying biological etiology of glioma. Our study suggests sex may play a role in genetic susceptibility and highlights the importance of sex-spec...

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Veröffentlicht in:	Cancer research communications 2024-11, Vol.4 (11), p.2933-2946
Hauptverfasser:	Alpen, Karen, Maclnnis, Robert J, Vajdic, Claire M, Lai, John, Dowty, James G, Koh, Eng-Siew, Hovey, Elizabeth, Harrup, Rosemary, Nguyen, Tuong L, Li, Shuai, Joseph, David, Benke, Geza, Dugué, Pierre-Antoine, Southey, Melissa C, Giles, Graham G, Nowak, Anna K, Drummond, Katharine J, Schmidt, Daniel F, Hopper, John L, Kapuscinski, Miroslaw K, Makalic, Enes
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - genetics Female Genetic Predisposition to Disease Genome-Wide Association Study Glioma - genetics Humans Male Polymorphism, Single Nucleotide
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Zusammenfassung:	Further investigation of the potential susceptibility regions identified in our study may lead to a better understanding of glioma genetic risk and the underlying biological etiology of glioma. Our study suggests sex may play a role in genetic susceptibility and highlights the importance of sex-specific analysis in future glioma research.
ISSN:	2767-9764 2767-9764
DOI:	10.1158/2767-9764.CRC-24-0385