Persistent SARS-CoV-2 infection resolved after B-cell recovery in a patient with follicular lymphoma treated with B-cell depletion therapy

A 68-year-old woman with follicular lymphoma was treated with chemotherapy, including the anti-CD20 monoclonal antibody obinutuzumab, and achieved remission. A month after the administration of obinutuzumab, the patient contracted coronavirus disease 2019 (COVID-19), and various antiviral drugs were...

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Veröffentlicht in:	Respiratory medicine case reports 2024-01, Vol.52, p.102131, Article 102131
Hauptverfasser:	Sueda, Yuriko, Tokuyasu, Hirokazu, Atsuta, Momoka, Sakai, Hiromitsu, Arai, Katsunori, Esumi, Chika, Mochizuki, Misato, Itohara, Tomoki, Fujisawa, Naoki, Yamasaki, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-CD20 antibody B-cell depletion therapy Case Report Follicular lymphoma Obinutuzumab Persistent SARS-CoV-2 infection
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Beschreibung
Zusammenfassung:	A 68-year-old woman with follicular lymphoma was treated with chemotherapy, including the anti-CD20 monoclonal antibody obinutuzumab, and achieved remission. A month after the administration of obinutuzumab, the patient contracted coronavirus disease 2019 (COVID-19), and various antiviral drugs were administered. However, the infection had not been eliminated. One year and three months after chemotherapy, peripheral B cell recovery was achieved, and the infection had resolved. This report provides insight into the course of COVID-19 in patients with impaired humoral immunity.
ISSN:	2213-0071 2213-0071
DOI:	10.1016/j.rmcr.2024.102131