Structural characterization of a novel glycosyl-phosphatidylinositol from the protozoan Tetrahymena mimbres

A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Man alpha 1-2Man alpha 1-4Man alpha 1...

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Veröffentlicht in:	Biochemical journal 1991-10, Vol.279 (2), p.605-608
Hauptverfasser:	WEINHART, U, THOMAS, J. R, PAK, Y, THOMPSON, G. A, FERGUSON, M. A. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Carbohydrate Sequence cell membranes Fundamental and applied biological sciences. Psychology glycolipids Glycolipids - chemistry Glycolipids - metabolism glycosylphosphatidylinositol Glycosylphosphatidylinositols Lipids Miscellaneous Molecular Sequence Data Molecular Structure Other biological molecules Phosphatidylinositol Diacylglycerol-Lyase Phosphatidylinositols - chemistry Phosphatidylinositols - metabolism Phosphoinositide Phospholipase C Phosphoric Diester Hydrolases - metabolism Sequence Homology, Nucleic Acid Tetrahymena - chemistry
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Zusammenfassung:	A glycolipid metabolically labelled with [14C]GlcN was isolated from the free-living protozoan Tetrahymena mimbres. The glycolipid was sensitive to a bacterial phosphatidylinositol-specific phospholipase C, and the headgroup was shown to contain a phosphorylated Man alpha 1-2Man alpha 1-4Man alpha 1-4GlcN glycan. The Tetrahymena glycolipid is structurally unique among the glycosylphosphatidylinositols that have so far been characterized, including those from several protozoan parasites of humans.
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2790605