Synthesis, Cytotoxicity, and Mechanistic Evaluation of Tetrahydrocurcumin-Amino Acid Conjugates as LAT1-Targeting Anticancer Agents in C6 Glioma Cells

Glioblastoma, a fatal brain cancer with limited treatments and poor prognosis, could benefit from targeting the L-type amino acid transporter I (LAT1). LAT1 is essential for cancer cells to acquire necessary amino acids. Tetrahydrocurcumin (THC), a key curcumin derivative, shows potential for gliobl...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2024-10, Vol.25 (20), p.11266
Hauptverfasser:	Teerawonganan, Polsak, Hasriadi, Dasuni Wasana, Peththa Wadu, Angsuwattana, Pornpoom, Suksamrarn, Apichart, Nalinratana, Nonthaneth, Vajragupta, Opa, Towiwat, Pasarapa, Thitikornpong, Worathat, Rojsitthisak, Pornchai
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Amino Acids - chemistry Analysis Animals Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis - drug effects Brain cancer Brain Neoplasms - drug therapy Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain tumors Cancer Cancer therapies Carbamates Care and treatment Cell death Cell Line, Tumor Cell Proliferation - drug effects Curcumin - analogs & derivatives Curcumin - chemical synthesis Curcumin - chemistry Curcumin - pharmacology Cytotoxicity Drug therapy Drugs Glioma Glioma - drug therapy Glioma - metabolism Glioma - pathology Gliomas Glycine Health aspects Humans Large Neutral Amino Acid-Transporter 1 - metabolism Medical prognosis Pharmacokinetics Phenylalanine Prognosis Radiation therapy Rats Spectrum analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!