Amino acid metabolism in tumour-bearing mice

Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skele...

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Veröffentlicht in:	Biochemical journal 1988-01, Vol.249 (2), p.443-449
Hauptverfasser:	Rivera, S, Azcón-Bieto, J, López-Soriano, F J, Miralpeix, M, Argilés, J M
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Amino Acids - metabolism Animals carcinoma Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - metabolism Glucose - metabolism Glutaminase - metabolism glutamine Lipid Metabolism Liver - metabolism lung Lung Neoplasms - enzymology Lung Neoplasms - metabolism Mice Mice, Inbred C57BL Muscles - metabolism Neoplasm Transplantation Proteins - metabolism
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Beschreibung
Zusammenfassung:	Mice bearing the Lewis lung carcinoma showed a high tumour glutaminase activity and significantly higher concentrations of most amino acids than in both the liver and the skeletal muscle of the host. Tumour tissue slices showed a marked preference for glutamine, especially for oxidation of its skeleton to CO2. It is proposed that the metabolism of this particular carcinoma is focused on amino acid degradation, glutamine being its preferred substrate.
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2490443