Association of the rs9896052 Polymorphism Upstream of GRB2 with Proliferative Diabetic Retinopathy in Patients with Less than 10 Years of Diabetes

Growth factor receptor-bound protein 2 (GRB2) is a negative regulator of insulin signaling and a positive regulator of angiogenesis. Its expression is increased in a mouse model of retinal neovascularization and in patients with type 2 diabetes mellitus (T2DM). This case-control study aimed to inves...

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Veröffentlicht in:	International journal of molecular sciences 2024-10, Vol.25 (19), p.10232
Hauptverfasser:	Bastos, Caroline Moura Cardoso, da Silva Machado, Lucas Marcelo, Crispim, Daisy, Canani, Luís Henrique, Dos Santos, Kátia Gonçalves
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Angiogenesis Blood & organ donations Body mass index Brazil Case-Control Studies Cholesterol Communication Complications and side effects Cytokines Development and progression Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Diabetic retinopathy Diabetic Retinopathy - genetics Female Gene Frequency Genetic aspects Genetic Predisposition to Disease Genotype Genotype & phenotype GRB2 Adaptor Protein - genetics Growth factors Health aspects Hemoglobin High density lipoprotein Humans Hyperglycemia Insulin Kinases Male Middle Aged Neovascularization Physiological aspects Polymorphism Polymorphism, Single Nucleotide Proteins Regression analysis Retina Risk factors Signal transduction Single nucleotide polymorphisms Skin Type 2 diabetes
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Zusammenfassung:	Growth factor receptor-bound protein 2 (GRB2) is a negative regulator of insulin signaling and a positive regulator of angiogenesis. Its expression is increased in a mouse model of retinal neovascularization and in patients with type 2 diabetes mellitus (T2DM). This case-control study aimed to investigate the association between the rs9896052 polymorphism (A>C) upstream of and proliferative diabetic retinopathy (PDR) in patients with T2DM from Southern Brazil, taking into consideration self-reported skin color (white or non-white) and the known duration of diabetes (
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms251910232