A novel acyl-CoA-binding protein from bovine liver. Effect on fatty acid synthesis

Bovine liver was shown to contain a hitherto undescribed medium-chain acyl-CoA-binding protein. The protein co-purifies with fatty-acid-binding proteins, but was, unlike these proteins, unable to bind fatty acids. The protein induced synthesis of medium-chain acyl-CoA esters on incubation with goat...

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Veröffentlicht in:	Biochemical journal 1987-01, Vol.241 (1), p.189-192
Hauptverfasser:	Mogensen, I B, Schulenberg, H, Hansen, H O, Spener, F, Knudsen, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Carrier Proteins - pharmacology Cattle Chromatography, Gel Electrophoresis, Polyacrylamide Gel Fatty Acid Synthases - metabolism Fatty Acid-Binding Proteins Fatty Acids - biosynthesis Female Goats Isoelectric Focusing Lactation - metabolism Liver - metabolism Mammary Glands, Animal - drug effects Mammary Glands, Animal - enzymology Neoplasm Proteins Pregnancy
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Beschreibung
Zusammenfassung:	Bovine liver was shown to contain a hitherto undescribed medium-chain acyl-CoA-binding protein. The protein co-purifies with fatty-acid-binding proteins, but was, unlike these proteins, unable to bind fatty acids. The protein induced synthesis of medium-chain acyl-CoA esters on incubation with goat mammary-gland fatty acid synthetase. The possible function of the protein is discussed.
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2410189