Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22–24 weeks’ gestational age

Risk factors and epidemiology of spontaneous intestinal perforation among infants born at 22–24 weeks’ gestational age

Objective To describe the epidemiology, risk factors, and timing of spontaneous intestinal perforation (SIP) among infants born at 22–24 weeks’ gestational age (GA). Study design Observational cohort study among infants born at 22–24 weeks’ GA in 446 neonatal intensive care units. Results We identif...

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Veröffentlicht in:Journal of perinatology 2024-01, Vol.44 (1), p.94-99
Hauptverfasser: Thakkar, Pavan V., Sutton, Kent F., Detwiler, Chloe-Ann B., Henegar, Julia G., Narayan, Jai R., Perez-Romero, Melanie, Strausser, Ciara M., Clark, Reese H., Benjamin, Daniel K., Zimmerman, Kanecia O., Goldberg, Ronald N., Younge, Noelle, Tanaka, David, Brian Smith, P., Greenberg, Rachel G., Kilpatrick, Ryan
Format: Artikel
Sprache:eng
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Antibiotics
Birth weight
Cohort analysis
Data warehouses
Epidemiology
Exposure
Female
Gastrointestinal diseases
Gestational Age
Hospitals
Humans
Hydrocortisone
Indomethacin
Indomethacin - adverse effects
Infant
Infant, Newborn
Infants
Insulin-like growth factors
Intensive care
Intensive care units
Intestinal Perforation - chemically induced
Intestinal Perforation - etiology
Intestine
Magnesium
Medicine
Medicine & Public Health
Mortality
Neonates
Observational studies
Pediatric Surgery
Pediatrics
Population
Pregnancy
Retrospective Studies
Risk Factors
Steroids
Variables
Weight Loss
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Zusammenfassung:Objective To describe the epidemiology, risk factors, and timing of spontaneous intestinal perforation (SIP) among infants born at 22–24 weeks’ gestational age (GA). Study design Observational cohort study among infants born at 22–24 weeks’ GA in 446 neonatal intensive care units. Results We identified 9712 infants, of whom 379 (3.9%) developed SIP. SIP incidence increased with decreasing GA ( P  20% (OR 2.04; 95% CI, 1.46–2.85) of birth weight had higher odds of SIP than infants with weight loss
ISSN:0743-8346
1476-5543
1476-5543
DOI:10.1038/s41372-023-01782-6