Immunohistochemical Expression of Calretinin in Dentigerous Cyst Transforming Into Unicystic Ameloblastoma: A Case Report

The term "unicystic ameloblastoma" describes cystic lesions that exhibit radiographic, clinical, or gross characteristics of a jaw cyst. However, histologic examination reveals a typical ameloblastomatous epithelium lining the cyst cavity, with or without luminal and/or mural tumor proliferation. Unicystic ameloblastoma is a less prevalent kind of ameloblastoma. Among the odontogenic cysts, neoplastic transformation is highest in odontogenic keratocysts (OKCs) and dentigerous cysts (DCs). Calretinin is considered a specific immunohistochemical marker for neoplastic ameloblastic epithelium and serves as a diagnostic tool for differentiating odontogenic cystic lesions from ameloblastic tumors. This paper illustrates a case of a DC transforming into unicystic ameloblastoma in a 22-year-old male patient using the immunohistochemical expression of calretinin.