Does complete resection of infected bone improve clinical outcomes in patients with diabetic foot osteomyelitis?

The objective of the study was to compare outcomes in patients with complete surgical resection versus partial resection of diabetic foot osteomyelitis (OM). A post hoc analysis of 171 patients with OM was performed using data from two randomized clinical trials. OM was confirmed with bone culture o...

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Veröffentlicht in:International wound journal 2024-10, Vol.21 (10), p.e70072-n/a
Hauptverfasser: Lavery, Lawrence A., Tarricone, Arthur N., Reyes, Mario C., Suludere, Mehmet A., Sideman, Matthew J., Siah, Michael C., Peters, Edgar J. G., Wukich, Dane K.
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Sprache:eng
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Zusammenfassung:The objective of the study was to compare outcomes in patients with complete surgical resection versus partial resection of diabetic foot osteomyelitis (OM). A post hoc analysis of 171 patients with OM was performed using data from two randomized clinical trials. OM was confirmed with bone culture or histopathology. Surgical culture specimens were obtained from resected bone and sent for histopathology and microbiology. Residual osteomyelitis (RO) was defined as a positive resected margin on culture or histopathology. No residual osteomyelitis (NRO) was defined as no growth from bone culture and no histopathological inflammation in the biopsy of the resection margin. Data from the 12‐month follow‐up were used to determine clinical outcomes. During the index hospitalization, NRO patients had significantly shorter duration of antibiotic therapy (NRO 21.0, 13.0–38.0 vs. RO 37.0, 20.8–50.0, p
ISSN:1742-4801
1742-481X
1742-481X
DOI:10.1111/iwj.70072