8287 Maternal Factors Associated with Oxidative Stress in Newborns of Women with Gestational Diabetes Mellitus

Abstract Disclosure: A. Valdez Gonzalez: None. R.A. Gomez-Diaz: None. M. Ruiz: None. S. Ángeles Mejía: None. M. Díaz-Flores: None. E. González Carranza: None. M. Ramos Cervantes: None. L. Ramirez Garcia: None. M. Diaz Velazquez: None. G. Acevedo Rodriguez: None. N. Wacher: None. Introduction: In gestational diabetes mellitus (GDM), oxidative stress is increased. However, the maternal factors that are linked to elevated oxidative stress markers in neonates, in addition to GDM, and their impact on fetal programming are still unclear and warrant further study. Objective: To evaluate maternal factors associated with elevated oxidative stress markers in newborns of mothers with and without GDM. Material and Methods Design: prospective cohort. Women with and without GDM in the third trimester of pregnancy were included. Oxidative stress markers [malondialdehyde (MDA), reduced glutathione (GSH), antioxidant capacity (measured by DPPH)], lipid profile, were measured in maternal serum at the end of pregnancy and umbilical cord blood. Maternal and newborn anthropometric data were recorded. Information on food intake was collected using a food frequency questionnaire in the third trimester of pregnancy. Statistical analysis: Variables were analyzed with Mann-Whitney U and multiple linear regression using the SPSS program. Values of p0.001) and antioxidant capacity (R2 0.289, p0.001). Maternal factors predicting newborn antioxidant capacity were: GDM (β 6.981, p=0.003), weight gain during pregnancy (β -0.461, p=0.024), maternal MDA (β -0.337, p=0.001) and antioxidant capacity (β 0.279, p