8250 The Impact of Inflammatory bowel disease on Outcomes for Osteoporotic fractures (OF) hospitalization Using the National Inpatient Sample Database

Abstract Disclosure: S. Khan: None. L. Zia: None. M. Khan: None. M. Amin: None. M. Khan: None. F. Sattar: None. Background: Osteoporosis has a significant implication on healthcare system with increasing hospitalizations for fractures, disabilities, and causing individual financial burden. Patients with Inflammatory bowel disease (IBD) are at higher risk of developing osteopenia and osteoporosis than the general population. We aimed to investigate the effects of sociodemographic of patients and outcomes for OF admissions with or without IBD. Methods: Data were obtained from the National Inpatient Sample, 2020, provided by the Healthcare Cost and Utilization project. This data represents 20% of admissions in the USA, weighted to represent the entire country. Our primary outcome was inpatient mortality, while the secondary outcomes were hospital length of stay (LOS), and total hospitalization charges (THC). We conducted the analysis using STATA software version 18.0, multivariate regression analysis was used to adjust for potential confounders. Results: Among 32 million hospitalizations, we found 60,890 admissions with a principal diagnosis of OF, 730 (1.2%) had concomitant IBD. Our study indicated that patients admitted with IBD were younger (72.63 Vs 78.35 P ≤ 0.05), more likely to be white (91.7% Vs 85.6%) and had higher Chronic steroid use (8.8% Vs 4.3, P = 0.02). The number of patients died during hospitalization for OF were 1455, 2.3% in non-IBD and 4% with IBD. There was no significant difference in inpatient mortality of patients admitted for OF with or without IBD, Crude Odds ratio of Mortality 1.75 (95% CI 0.77-3.98) and adjusted odds ratio of Mortality 2.03 (95% CI 0.86-4.82). Multivariable analysis revealed that Age (OR= 1.02; 95% CI 1.009-1.03), female (OR= 0.58; 95% CI 0.45-0.75), Charlson Comorbidity Index (OR= 1.22; 95% CI 1.18-1.1.27) were predictors of Mortality. Among secondary outcomes, there was no significant difference in LOS (Adjusted Mean difference 0.69, P= 0.27), THC (Adjusted Mean difference 5331, P=0.430). Mean LOS in hospital for OF was 6.16 days and Mean THC was 77652 USD. Conclusion: National admissions data indicates that hospitalizations for Osteoporotic fractures with or without IBD showed no significant difference in inpatient mortality, Length of stay in the hospital and total hospitalization charges. Despite lack of statistical difference, clinical relevance is important given greater mortality in OF with IBD. As physici