KAT tales: Functions of Gcn5 and PCAF lysine acetyltransferases in SAGA and ATAC

The Allis group identified Gcn5 as the first transcription-related lysine acetyltransferase in 1996, providing a molecular “missing link” between chromatin organization and gene regulation. This review will focus on functions subsequently identified for Gcn5 and the closely related PCAF protein, in...

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Veröffentlicht in:	The Journal of biological chemistry 2024-10, Vol.300 (10), p.107744, Article 107744
1. Verfasser:	Dent, Sharon Y.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Animals ATAC cancer Chromatin - genetics Chromatin - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Gcn5 histone acetylation Histone Acetyltransferases - genetics Histone Acetyltransferases - metabolism Humans JBC Reviews Lysine - metabolism Lysine Acetyltransferases - genetics Lysine Acetyltransferases - metabolism neural degeneration p300-CBP Transcription Factors - genetics p300-CBP Transcription Factors - metabolism PCAF SAGA Trans-Activators - genetics Trans-Activators - metabolism
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Beschreibung
Zusammenfassung:	The Allis group identified Gcn5 as the first transcription-related lysine acetyltransferase in 1996, providing a molecular “missing link” between chromatin organization and gene regulation. This review will focus on functions subsequently identified for Gcn5 and the closely related PCAF protein, in the context of two major complexes, SAGA and ATAC, and how the study of these enzymes informs long standing questions regarding the importance of lysine acetylation.
ISSN:	0021-9258 1083-351X 1083-351X
DOI:	10.1016/j.jbc.2024.107744