Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure
Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal ne...
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| Veröffentlicht in: | British journal of surgery 1996-10, Vol.83 (10), p.1407-1412 |
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| container_title | British journal of surgery |
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| creator | Botha, A. J. Moore, F. A. Moore, E. E. Peterson, V. M. Silliman, C. C. Goode, A. W. |
| description | Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1·26(0·19), 1·33(0·26), 1·04(0·14) and 0·86(0·13) nmol superoxide per min per 1·3 × 106 neutrophils respectively (P |
| doi_str_mv | 10.1002/bjs.1800831027 |
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J. ; Moore, F. A. ; Moore, E. E. ; Peterson, V. M. ; Silliman, C. C. ; Goode, A. W.</creator><creatorcontrib>Botha, A. J. ; Moore, F. A. ; Moore, E. E. ; Peterson, V. M. ; Silliman, C. C. ; Goode, A. W.</creatorcontrib><description>Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1·26(0·19), 1·33(0·26), 1·04(0·14) and 0·86(0·13) nmol superoxide per min per 1·3 × 106 neutrophils respectively (P<0·05). Priming at 3 h after injury was inhibited by mean(s.e.m.) 63·8(7·0) per cent by the PAF antagonist, WEB 2170 (P<0·01). Mean(s.e.m.) plasma IL‐8 was raised at 6 and 12 h after injury to 785(183) and 836(175) pg/ml (P<0·01). At 12 h after injury the plasma IL‐8 level correlated directly with the number of units of red blood cells transfused (r=0·64, P<0·01), and was significantly higher in the group of six patients who developed MOF (P<0·05). These data suggest that after trauma the mediators PAF and IL‐8 appear sequentially in the circulation, are potential mechanisms of circulating neutrophil priming, and that IL‐8 may also be an early biochemical marker predicting the onset of MOF.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800831027</identifier><identifier>PMID: 8944457</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Association of Surgeon ; Biological and medical sciences ; Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care ; Female ; Humans ; Injury Severity Score ; Intensive care medicine ; Interleukin-8 - metabolism ; Male ; Medical sciences ; Middle Aged ; Multiple Organ Failure - diagnosis ; Multiple Organ Failure - metabolism ; Neutrophils - physiology ; Platelet Activating Factor - metabolism ; Time Factors ; Wounds and Injuries - metabolism</subject><ispartof>British journal of surgery, 1996-10, Vol.83 (10), p.1407-1412</ispartof><rights>Copyright © 1996 British Journal of Surgery Society Ltd.</rights><rights>1996 INIST-CNRS</rights><rights>Copyright © 1996 British Journal of Surgery Society Ltd. 1996</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4647-83b022504d3931d0debe2bf23b87e6481f4bac08b3971802be1c9bad612d675c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800831027$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800831027$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,309,310,314,780,784,789,790,885,1417,23930,23931,25140,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3241368$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8944457$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Botha, A. J.</creatorcontrib><creatorcontrib>Moore, F. A.</creatorcontrib><creatorcontrib>Moore, E. E.</creatorcontrib><creatorcontrib>Peterson, V. M.</creatorcontrib><creatorcontrib>Silliman, C. C.</creatorcontrib><creatorcontrib>Goode, A. W.</creatorcontrib><title>Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1·26(0·19), 1·33(0·26), 1·04(0·14) and 0·86(0·13) nmol superoxide per min per 1·3 × 106 neutrophils respectively (P<0·05). Priming at 3 h after injury was inhibited by mean(s.e.m.) 63·8(7·0) per cent by the PAF antagonist, WEB 2170 (P<0·01). Mean(s.e.m.) plasma IL‐8 was raised at 6 and 12 h after injury to 785(183) and 836(175) pg/ml (P<0·01). At 12 h after injury the plasma IL‐8 level correlated directly with the number of units of red blood cells transfused (r=0·64, P<0·01), and was significantly higher in the group of six patients who developed MOF (P<0·05). These data suggest that after trauma the mediators PAF and IL‐8 appear sequentially in the circulation, are potential mechanisms of circulating neutrophil priming, and that IL‐8 may also be an early biochemical marker predicting the onset of MOF.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Association of Surgeon</subject><subject>Biological and medical sciences</subject><subject>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</subject><subject>Female</subject><subject>Humans</subject><subject>Injury Severity Score</subject><subject>Intensive care medicine</subject><subject>Interleukin-8 - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multiple Organ Failure - diagnosis</subject><subject>Multiple Organ Failure - metabolism</subject><subject>Neutrophils - physiology</subject><subject>Platelet Activating Factor - metabolism</subject><subject>Time Factors</subject><subject>Wounds and Injuries - metabolism</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUk1vFCEYJkZT1-rVmwkH420qXzMwJ2M3btU0alKNxgsBhtmlyzAjMK37I_zP0uxmqycgz8f78j4vAM8xOsMIkdf6Op1hgZCgGBH-ACwwbeqK4EY8BAuEEK8wJfQxeJLSNUKYopqcgBPRMsZqvgB_ruyv2YbslIdpl7IdnIGTV9l6mytlsrtR2YU17Mt9jFCFDrqQbfR23roABZyiG2yCwc45jtPG-VQIcCqqYpvgrcsbmKOaBwVVhtGlLRx7OMw-u8lbOMa1CsXd-Tnap-BRr3yyzw7nKfi2evd1-b66_HzxYfn2sjKsYbwSVCNCasQ62lLcoc5qS3RPqBbcNkzgnmllkNC05WU2RFtsWq26BpOu4bWhp-DN3nea9WA7UzqNysu7r6i4k6Ny8n8kuI1cjzcSY0YFIW1xeHVwiGMZYMpycMlY71Ww45wkFzWnQpBCfPFvqWONQwIFf3nAVTLK91EF49KRRgkrgYpCa_e0W-ft7ghjJO-2QJYtkPdbIM8_Xt2_irbaa13J9_dRq-JWNpzyWn7_dCFXZMW_LH_8lEv6F7G6uW4</recordid><startdate>199610</startdate><enddate>199610</enddate><creator>Botha, A. J.</creator><creator>Moore, F. A.</creator><creator>Moore, E. E.</creator><creator>Peterson, V. M.</creator><creator>Silliman, C. C.</creator><creator>Goode, A. W.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>199610</creationdate><title>Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure</title><author>Botha, A. J. ; Moore, F. A. ; Moore, E. E. ; Peterson, V. M. ; Silliman, C. C. ; Goode, A. W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4647-83b022504d3931d0debe2bf23b87e6481f4bac08b3971802be1c9bad612d675c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Association of Surgeon</topic><topic>Biological and medical sciences</topic><topic>Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care</topic><topic>Female</topic><topic>Humans</topic><topic>Injury Severity Score</topic><topic>Intensive care medicine</topic><topic>Interleukin-8 - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multiple Organ Failure - diagnosis</topic><topic>Multiple Organ Failure - metabolism</topic><topic>Neutrophils - physiology</topic><topic>Platelet Activating Factor - metabolism</topic><topic>Time Factors</topic><topic>Wounds and Injuries - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Botha, A. J.</creatorcontrib><creatorcontrib>Moore, F. A.</creatorcontrib><creatorcontrib>Moore, E. E.</creatorcontrib><creatorcontrib>Peterson, V. M.</creatorcontrib><creatorcontrib>Silliman, C. C.</creatorcontrib><creatorcontrib>Goode, A. W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Botha, A. J.</au><au>Moore, F. A.</au><au>Moore, E. E.</au><au>Peterson, V. M.</au><au>Silliman, C. C.</au><au>Goode, A. W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1996-10</date><risdate>1996</risdate><volume>83</volume><issue>10</issue><spage>1407</spage><epage>1412</epage><pages>1407-1412</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1·26(0·19), 1·33(0·26), 1·04(0·14) and 0·86(0·13) nmol superoxide per min per 1·3 × 106 neutrophils respectively (P<0·05). Priming at 3 h after injury was inhibited by mean(s.e.m.) 63·8(7·0) per cent by the PAF antagonist, WEB 2170 (P<0·01). Mean(s.e.m.) plasma IL‐8 was raised at 6 and 12 h after injury to 785(183) and 836(175) pg/ml (P<0·01). At 12 h after injury the plasma IL‐8 level correlated directly with the number of units of red blood cells transfused (r=0·64, P<0·01), and was significantly higher in the group of six patients who developed MOF (P<0·05). These data suggest that after trauma the mediators PAF and IL‐8 appear sequentially in the circulation, are potential mechanisms of circulating neutrophil priming, and that IL‐8 may also be an early biochemical marker predicting the onset of MOF.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>8944457</pmid><doi>10.1002/bjs.1800831027</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of surgery, 1996-10, Vol.83 (10), p.1407-1412 |
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| source | MEDLINE; Wiley Journals; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Association of Surgeon Biological and medical sciences Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Female Humans Injury Severity Score Intensive care medicine Interleukin-8 - metabolism Male Medical sciences Middle Aged Multiple Organ Failure - diagnosis Multiple Organ Failure - metabolism Neutrophils - physiology Platelet Activating Factor - metabolism Time Factors Wounds and Injuries - metabolism |
| title | Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure |
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