Sequential systemic platelet-activating factor and interleukin 8 primes neutrophils in patients with trauma at risk of multiple organ failure

Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal ne...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	British journal of surgery 1996-10, Vol.83 (10), p.1407-1412
Hauptverfasser:	Botha, A. J., Moore, F. A., Moore, E. E., Peterson, V. M., Silliman, C. C., Goode, A. W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Association of Surgeon Biological and medical sciences Emergency and intensive cardiocirculatory care. Cardiogenic shock. Coronary intensive care Female Humans Injury Severity Score Intensive care medicine Interleukin-8 - metabolism Male Medical sciences Middle Aged Multiple Organ Failure - diagnosis Multiple Organ Failure - metabolism Neutrophils - physiology Platelet Activating Factor - metabolism Time Factors Wounds and Injuries - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Plasma from 33 patients at risk of multiple organ failure (MOF) after major trauma was tested for a priming effect on neutrophils, and for the presence of platelet‐activating factor (PAF) activity and interleukin (IL) 8. Plasma sampled at 3, 6, 12 and 24 h after injury significantly primed normal neutrophils to release mean(s.e.m.) 1·26(0·19), 1·33(0·26), 1·04(0·14) and 0·86(0·13) nmol superoxide per min per 1·3 × 106 neutrophils respectively (P
ISSN:	0007-1323 1365-2168
DOI:	10.1002/bjs.1800831027