Two new sphingomyelin analogues inhibit phosphatidylcholine biosynthesis by decreasing membrane-bound CTP: phosphocholine cytidylyltransferase levels in HaCaT cells

The effects of two newly synthesized sphingomyelin analogues on phosphatidylcholine biosynthesis were investigated in the immortalized human keratinocyte cell line HaCaT. N-Acetyl-erythro-sphingosine-1-phosphocholine (AcSM) and N-octanoyl-erythro-sphingosine-1-phosphocholine (OcSM) inhibited the inc...

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Veröffentlicht in:	Biochemical journal 1995-11, Vol.311 ( Pt 3) (3), p.873-879
Hauptverfasser:	Wieder, T, Perlitz, C, Wieprecht, M, Huang, R T, Geilen, C C, Orfanos, C E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - metabolism Animals Cell Line Cell Membrane - enzymology Cell Survival - drug effects Choline - analogs & derivatives Choline - metabolism Choline-Phosphate Cytidylyltransferase Enzyme Activation Enzyme Inhibitors - pharmacology Humans Keratinocytes - drug effects Keratinocytes - enzymology Keratinocytes - metabolism Kinetics Nucleotidyltransferases - antagonists & inhibitors Nucleotidyltransferases - metabolism Phosphatidylcholines - biosynthesis Rats Sphingomyelins - chemical synthesis Sphingomyelins - pharmacokinetics Sphingomyelins - pharmacology Tritium
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