Bioinformatics Analysis of the Genome of Rhodococcus rhodochrous IEGM 1362, an (-)-Isopulegol Biotransformer

A genome of IEGM 1362 was sequenced and annotated. This strain can transform monoterpene alcohol (-)-isopulegol with the formation of two novel pharmacologically promising metabolites. Nine genes encoding cytochrome P450, presumably involved in (-)-isopulegol transformation, were found in the genome...

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Veröffentlicht in:	Genes 2024-07, Vol.15 (8), p.992
Hauptverfasser:	Maltseva, Polina Yu, Plotnitskaya, Natalia A, Krivoruchko, Anastasiia V, Beletskiy, Aleksey V, Rakitin, Andrey L, Mardanov, Andrey V, Ivshina, Irina B
Format:	Artikel
Sprache:	eng
Schlagworte:	alcohols Analysis Bioinformatics Biotransformation Biotransformation - genetics Computational biology Computational Biology - methods Control cytochrome P-450 Cytochrome P-450 Enzyme System - genetics Cytochrome P-450 Enzyme System - metabolism Cytochrome P450 Enzymes Essences and essential oils Genes Genetic aspects genome Genome, Bacterial Genomes Genomic analysis Gram-positive bacteria Health aspects Identification and classification Metabolites Microorganisms Monoterpenes - metabolism monoterpenoids Phylogenetics Rhodococcus - genetics Rhodococcus - metabolism Rhodococcus rhodochrous
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Beschreibung
Zusammenfassung:	A genome of IEGM 1362 was sequenced and annotated. This strain can transform monoterpene alcohol (-)-isopulegol with the formation of two novel pharmacologically promising metabolites. Nine genes encoding cytochrome P450, presumably involved in (-)-isopulegol transformation, were found in the genome of IEGM 1362. Primers and PCR conditions for their detection were selected. The obtained data can be used for the further investigation of genes encoding enzymes involved in monoterpene biotransformation.
ISSN:	2073-4425 2073-4425
DOI:	10.3390/genes15080992