The structure of the human glutathione S-transferase pi gene

The structure of the human glutathione S-transferase pi gene

The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at...

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Veröffentlicht in:Biochemical journal 1988-10, Vol.255 (1), p.79-83
Hauptverfasser: Cowell, I G, Dixon, K H, Pemble, S E, Ketterer, B, Taylor, J B
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Base Sequence
Binding Sites
Blotting, Southern
Cloning, Molecular
Genes
Glutathione Transferase - genetics
Humans
Isoenzymes - genetics
Molecular Sequence Data
Promoter Regions, Genetic
Transcription, Genetic
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Zusammenfassung:The human glutathione S-transferase pi gene has been isolated from a cosmid library. The gene spans approximately 3 kb, is interrupted by six introns and the region around its 5' end has the high G + C and CpG content typical of an HTF (HpaII tiny fragment) island. In addition to a TATA box at position -28 relative to the transcription initiation site and two G + C boxes (GGGCGG), the promoter contains a sequence motif matching the phorbol ester- and ras-responsive element from the polyoma virus enhancer.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2550079