On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration

On the mechanism of the increase in cardiolipin biosynthesis and resynthesis in hepatocytes during rat liver regeneration

CL (cardiolipin) is a major mitochondrial membrane phospholipid important for the regulation of mitochondrial function. We examined CL de novo biosynthesis and its resynthesis in isolated rat liver hepatocytes prepared 48 h subsequent to two-thirds PHx (partial hepatectomy). The pool size of CL and...

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Veröffentlicht in:Biochemical journal 2005-02, Vol.386 (Pt 1), p.137-143
Hauptverfasser: Webster, Jennifer, Jiang, Jenny Y, Lu, Biao, Xu, Fred Y, Taylor, William A, Mymin, Mathew, Zhang, Manna, Minuk, Gerald Y, Hatch, Grant M
Format: Artikel
Sprache:eng
Schlagworte:
Acyltransferases - analysis
Animals
Cardiolipins - biosynthesis
Hepatectomy
Hepatocytes - metabolism
Liver Regeneration - physiology
Mitochondria, Liver - enzymology
Phospholipids - analysis
Proliferating Cell Nuclear Antigen - analysis
Proteins - analysis
Rats
Rats, Sprague-Dawley
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - biosynthesis
Transferases (Other Substituted Phosphate Groups) - analysis
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Zusammenfassung:CL (cardiolipin) is a major mitochondrial membrane phospholipid important for the regulation of mitochondrial function. We examined CL de novo biosynthesis and its resynthesis in isolated rat liver hepatocytes prepared 48 h subsequent to two-thirds PHx (partial hepatectomy). The pool size of CL and its de novo biosynthesis from [1,3-(3)H]glycerol were increased 3.3-fold (P
ISSN:0264-6021
1470-8728
DOI:10.1042/BJ20040655