Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

A comparison was made of the phosphate content of the tight-junction-specific protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance, a parameter reflective of tight-junctional permeability. Analysis revealed that the ZO-1 from the low-resistance st...

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Veröffentlicht in:Biochemical journal 1989-10, Vol.263 (2), p.597-599
Hauptverfasser: Stevenson, B R, Anderson, J M, Braun, I D, Mooseker, M S
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Anderson, J M
Braun, I D
Mooseker, M S
description A comparison was made of the phosphate content of the tight-junction-specific protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance, a parameter reflective of tight-junctional permeability. Analysis revealed that the ZO-1 from the low-resistance strain contained approximately twice as much phosphate as that from the high-resistance strain.
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subjects Animals
Cell Line
Cell Membrane Permeability
Dogs
Electric Conductivity
Epithelium - physiology
Intercellular Junctions - physiology
Kidney - physiology
Kinetics
MDCK cells
Membrane Proteins - metabolism
Phosphates - metabolism
Phosphoproteins - metabolism
Phosphorylation
proteins
Zonula Occludens-1 Protein
title Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance
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