Phosphorylation of the tight-junction protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance

A comparison was made of the phosphate content of the tight-junction-specific protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance, a parameter reflective of tight-junctional permeability. Analysis revealed that the ZO-1 from the low-resistance st...

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Veröffentlicht in:	Biochemical journal 1989-10, Vol.263 (2), p.597-599
Hauptverfasser:	Stevenson, B R, Anderson, J M, Braun, I D, Mooseker, M S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line Cell Membrane Permeability Dogs Electric Conductivity Epithelium - physiology Intercellular Junctions - physiology Kidney - physiology Kinetics MDCK cells Membrane Proteins - metabolism Phosphates - metabolism Phosphoproteins - metabolism Phosphorylation proteins Zonula Occludens-1 Protein
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Zusammenfassung:	A comparison was made of the phosphate content of the tight-junction-specific protein ZO-1 in two strains of Madin-Darby canine kidney cells which differ in transepithelial resistance, a parameter reflective of tight-junctional permeability. Analysis revealed that the ZO-1 from the low-resistance strain contained approximately twice as much phosphate as that from the high-resistance strain.
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2630597