Cell shrinkage follows, rather than mediates, the short-term effects of glucagon on carbohydrate metabolism

The initial effects of glucagon on glycogen breakdown in isolated hepatocytes were found to be independent of cell volume and, when it occurred, cell shrinkage followed rather than mediated the glycogenolytic effect of glucagon. Similar conclusions could be drawn for the effect of glucagon on glycol...

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Veröffentlicht in:	Biochemical journal 1992-10, Vol.287 (1), p.17-20
Hauptverfasser:	GAUSSIN, V, BAQUET, A, HUE, L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell physiology Cell Size - drug effects Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology Glucagon - pharmacology Gluconeogenesis - drug effects Hormonal regulation In Vitro Techniques Insulin - pharmacology Liver - cytology Liver - metabolism Liver Glycogen - metabolism Male Molecular and cellular biology Phosphorylases - metabolism Pyruvate Kinase - metabolism Rats Rats, Wistar Water-Electrolyte Balance - drug effects
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Zusammenfassung:	The initial effects of glucagon on glycogen breakdown in isolated hepatocytes were found to be independent of cell volume and, when it occurred, cell shrinkage followed rather than mediated the glycogenolytic effect of glucagon. Similar conclusions could be drawn for the effect of glucagon on glycolysis/gluconeogenesis and for the antagonistic effect of insulin on glucagon action.
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2870017