The energy-splicing resilience axis hypothesis of aging

The energy-splicing resilience axis hypothesis of aging

Aging can be conceptualized as the stochastic accumulation of damage and loss of resilience leading to organism demise. Resilience mechanisms that repair, recycle or replace damaged molecules and organelles are energy-demanding, therefore energy availability is essential to healthy aging. We propose...

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Veröffentlicht in:Nature aging 2022-03, Vol.2 (3), p.182-185
Hauptverfasser: Ferrucci, Luigi, Wilson, 3rd, David M, Donegà, Stefano, Gorospe, Myriam
Format: Artikel
Sprache:eng
Schlagworte:
Age
Aging
Energy consumption
Exercise
Homeostasis
Hypotheses
Kinases
Metabolism
Mitochondria
Musculoskeletal system
Phosphorylation
Physiology
Protein expression
Proteins
RNA Splicing
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Zusammenfassung:Aging can be conceptualized as the stochastic accumulation of damage and loss of resilience leading to organism demise. Resilience mechanisms that repair, recycle or replace damaged molecules and organelles are energy-demanding, therefore energy availability is essential to healthy aging. We propose that changes in mitochondrial and energy status regulate RNA splicing and that splicing is a resilience strategy that preserves energetic homeostasis with aging.
ISSN:2662-8465
2662-8465
DOI:10.1038/s43587-022-00189-w