Hypertension and diabetes, but not leptin and adiponectin, mediate the relationship between body fat and chronic kidney disease

Hypertension and diabetes, but not leptin and adiponectin, mediate the relationship between body fat and chronic kidney disease

Purpose Obesity may promote kidney damage through hemodynamic and hormonal effects. We investigated the association between body mass index (BMI), total body fat (TBF) and chronic kidney disease (CKD) and whether hypertension, diabetes, leptin and adiponectin mediated these associations. Methods In...

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Veröffentlicht in:Endocrine 2024, Vol.85 (3), p.1141-1153
Hauptverfasser: Lengton, Robin, Dekker, Friedo W., van Rossum, Elisabeth F. C., de Fijter, Johan W., Rosendaal, Frits R., van Dijk, Ko Willems, Rabelink, Ton J., Le Cessie, Saskia, de Mutsert, Renée, Hoogeveen, Ellen K.
Format: Artikel
Sprache:eng
Schlagworte:
Adiponectin
Adiponectin - blood
Adipose Tissue - metabolism
Aged
Body fat
Body Mass Index
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Endocrinology
Epidemiology
Female
Humanities and Social Sciences
Humans
Hypertension
Hypertension - epidemiology
Internal Medicine
Kidney diseases
Leptin
Leptin - blood
Male
Medicine
Medicine & Public Health
Middle Aged
multidisciplinary
Netherlands - epidemiology
Obesity
Obesity - complications
Obesity - epidemiology
Original
Original Article
Physical activity
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - epidemiology
Science
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Zusammenfassung:Purpose Obesity may promote kidney damage through hemodynamic and hormonal effects. We investigated the association between body mass index (BMI), total body fat (TBF) and chronic kidney disease (CKD) and whether hypertension, diabetes, leptin and adiponectin mediated these associations. Methods In this cross-sectional analysis of the Netherlands Epidemiology of Obesity study, 6671 participants (45–65 y) were included. We defined CKD as eGFR
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-024-03811-6