Control of mitochondrial ATP synthesis in the heart

A number of recent reviews have dealt with the control of oxidative phosphorylation in the heart. In general, however, they have concentrated on the means employed by the cell to modulate the mitochondrial electron transfer chain; the ATP synthase was considered as essentially responding passively t...

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Veröffentlicht in:	Biochemical journal 1991-12, Vol.280 (3), p.561-573
Hauptverfasser:	HARRIS, D. A, DAS, A. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ATP ATPase Inhibitory Protein Biological and medical sciences Calcium - metabolism Cell physiology Down-Regulation Fundamental and applied biological sciences. Psychology heart mechanisms mitochondria Mitochondria, Heart - metabolism Molecular and cellular biology Proteins - metabolism Proton-Translocating ATPases - antagonists & inhibitors Proton-Translocating ATPases - metabolism regulation reviews Secretion. Exocytosis synthesis Up-Regulation
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Beschreibung
Zusammenfassung:	A number of recent reviews have dealt with the control of oxidative phosphorylation in the heart. In general, however, they have concentrated on the means employed by the cell to modulate the mitochondrial electron transfer chain; the ATP synthase was considered as essentially responding passively to changes in these other events. It is the aim of this Review to redress the balance and focus attention on the ATP synthase within heart mitochondria, and on its regulation.
ISSN:	0264-6021 1470-8728
DOI:	10.1042/bj2800561