Probing the efficacy of high-flow nasal cannula in the treatment of acute exacerbations of COPD with acute-moderate hypercapnic respiratory failure

[...]using lower flow rates might have influenced the study’s outcomes. [...]although the authors mention that carbon dioxide retention was the most common reason for failure in the HFNC group, pH levels at all study points were similar to those observed with NIV. [...]the Kaplan–Meier graph in Fig. 2 shows that until day 3, failure rates were comparable between the study arms. [...]all of the aforementioned factors may have contributed to the marginally statistically significant difference observed between the two groups in terms of treatment failure.