Biparametric versus multiparametric MRI for the detection of clinically significant prostate cancer in a diverse, multiethnic population

Purpose There is not yet satisfactory performance data comparing multiparametric MRI (mpMRI) versus biparametric MRI (bpMRI) for detecting prostate cancer (PCa), particularly in high-risk populations. We compared both protocols for detecting overall PCa and clinically significant PCa (CS-PCa; define...

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Veröffentlicht in:Abdominal imaging 2024-07, Vol.49 (7), p.2491-2498
Hauptverfasser: Abramson, Max, DeMasi, Matthew, Zhu, Denzel, Hines, Laena, Lin, Wilson, Kanmaniraja, Devaraju, Chernyak, Victoria, Agalliu, Ilir, Watts, Kara L.
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Sprache:eng
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Zusammenfassung:Purpose There is not yet satisfactory performance data comparing multiparametric MRI (mpMRI) versus biparametric MRI (bpMRI) for detecting prostate cancer (PCa), particularly in high-risk populations. We compared both protocols for detecting overall PCa and clinically significant PCa (CS-PCa; defined as Grade Group ≥ 2) in a multiethnic urban population. Methods We retrospectively reviewed electronic medical record data from men who underwent image-guided fusion prostate biopsy (FB) between 2016 and 2021 at our institution. Patient characteristics, Prostate Imaging Reporting and Data System (PI-RADS) scores, and FB outcomes were analyzed based on MRI protocol. Multivariate mixed-effects logistic regression models were used to examine associations of bpMRI versus mpMRI for detecting overall PCa and CS-PCa in targeted lesions, among all patients and stratified by race/ethnicity. Results Overall, 566 men (44.0% Non-Hispanic Black [NHB]; 27.0% Hispanic) with 975 PI-RADS 3–5 lesions on MRI underwent FB. Of these, 312 (55%) men with 497 lesions underwent mpMRI and 254 (45%) men with 478 lesions underwent bpMRI. On multivariate analyses among all men, the odds of detecting overall PCa (OR = 1.18, 95% CI: 1.05–3.11, p = 0.031) and CS-PCa (OR = 2.15, 95% CI: 1.16–4.00, p  = 0.014) on FB were higher for lesions identified on bpMRI than mpMRI. When stratified by race/ethnicity, the odds of detecting overall PCa (OR = 1.86; p  = 0.15) and CS-PCa (OR = 2.20; p  = 0.06) were not statistically different between lesions detected on bpMRI or mpMRI. Conclusion BpMRI has similar diagnostic performance to mpMRI in detecting overall and CS-PCa within a racially/ethnically diverse population. BpMRI can be utilized for evaluating suspected CS-PCa among NHB and Hispanic men.
ISSN:2366-0058
2366-004X
2366-0058
DOI:10.1007/s00261-024-04332-6