Biopsychosocial Factors Associated With Pain and Pain-Related Outcomes in Adults and Children With Sickle Cell Disease: A Multivariable Analysis of the GRNDaD Multicenter Registry

Pain is the primary symptomatic manifestation of sickle cell disease (SCD), an inherited hemoglobinopathy. The characteristics that influence pain experiences and outcomes in SCD are not fully understood. The primary objective of this study was to use multivariable modeling to examine associations o...

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Veröffentlicht in:The journal of pain 2024-01, Vol.25 (1), p.153-164
Hauptverfasser: Kenney, Martha O., Wilson, Samuel, Shah, Nirmish, Bortsov, Andrey, Smith, Wally R., Little, Jane, Lanzkron, Sophie, Kanter, Julie, Padrino, Susan, Owusu-Ansah, Amma, Cohen, Alice, Desai, Payal, Manwani, Deepa, Rehman, Sana Saif Ur, Hagar, Ward, Keefe, Francis
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Sprache:eng
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Zusammenfassung:Pain is the primary symptomatic manifestation of sickle cell disease (SCD), an inherited hemoglobinopathy. The characteristics that influence pain experiences and outcomes in SCD are not fully understood. The primary objective of this study was to use multivariable modeling to examine associations of biopsychosocial variables with a disease-specific measure of pain interference known as pain impact. We conducted a secondary analysis of data from the Global Research Network for Data and Discovery national SCD registry. A total of 657 children and adults with SCD were included in the analysis. This sample was 60% female with a median age of 34 (interquartile range 26–42 years) and a chronic pain prevalence of 64%. The model accounted for 58% of the variance in pain impact. Low social (P 
ISSN:1526-5900
1528-8447
1528-8447
DOI:10.1016/j.jpain.2023.07.029